| Literature DB >> 26068491 |
Erqi L Pollom1, Lei Deng1, Reetesh K Pai2, J Martin Brown1, Amato Giaccia1, Billy W Loo1, David B Shultz1, Quynh Thu Le1, Albert C Koong1, Daniel T Chang3.
Abstract
Combining the latest targeted biologic agents with the most advanced radiation technologies has been an exciting development in the treatment of cancer patients. Stereotactic body radiation therapy (SBRT) is an ablative radiation approach that has become established for the treatment of a variety of malignancies, and it has been increasingly used in combination with biologic agents, including those targeting angiogenesis-specific pathways. Multiple reports have emerged describing unanticipated toxicities arising from the combination of SBRT and angiogenesis-targeting agents, particularly of late luminal gastrointestinal toxicities. In this review, we summarize the literature describing these toxicities, explore the biological mechanism of action of toxicity with the combined use of antiangiogenic therapies, and discuss areas of future research, so that this combination of treatment modalities can continue to be used in broader clinical contexts.Entities:
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Year: 2015 PMID： 26068491 PMCID： PMC4816453 DOI： 10.1016/j.ijrobp.2015.02.016
Source DB: PubMed Journal: Int J Radiat Oncol Biol Phys ISSN： 0360-3016 Impact factor: 7.038