| Literature DB >> 26068415 |
Harmen H M Draisma1,2,3, René Pool1,2,4, Michael Kobl5, Rick Jansen6, Ann-Kristin Petersen5, Anika A M Vaarhorst4,7,8, Idil Yet9, Toomas Haller10, Ayşe Demirkan11,12, Tõnu Esko10,13,14,15, Gu Zhu16, Stefan Böhringer17, Marian Beekman7, Jan Bert van Klinken11, Werner Römisch-Margl18, Cornelia Prehn19, Jerzy Adamski19,20,21, Anton J M de Craen22, Elisabeth M van Leeuwen12, Najaf Amin12, Harish Dharuri11, Harm-Jan Westra23, Lude Franke23, Eco J C de Geus1,2, Jouke Jan Hottenga1,2, Gonneke Willemsen1,2, Anjali K Henders16, Grant W Montgomery16, Dale R Nyholt16,24, John B Whitfield16, Brenda W Penninx2,25, Tim D Spector9, Andres Metspalu10, P Eline Slagboom4,7, Ko Willems van Dijk11,26, Peter A C 't Hoen11, Konstantin Strauch5,27, Nicholas G Martin16, Gert-Jan B van Ommen11, Thomas Illig28,29,30, Jordana T Bell9, Massimo Mangino9, Karsten Suhre18,31,32, Mark I McCarthy33,34,35, Christian Gieger5,28,36, Aaron Isaacs12, Cornelia M van Duijn4,8,12, Dorret I Boomsma1,2,4.
Abstract
Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platform. In a discovery sample of 7,478 individuals of European descent, we find 4,068 genome- and metabolome-wide significant (Z-test, P < 1.09 × 10(-9)) associations between single-nucleotide polymorphisms (SNPs) and metabolites, involving 59 independent SNPs and 85 metabolites. Five of the fifty-nine independent SNPs are new for serum metabolite levels, and were followed-up for replication in an independent sample (N = 1,182). The novel SNPs are located in or near genes encoding metabolite transporter proteins or enzymes (SLC22A16, ARG1, AGPS and ACSL1) that have demonstrated biomedical or pharmaceutical importance. The further characterization of genetic influences on metabolic phenotypes is important for progress in biological and medical research.Entities:
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Year: 2015 PMID： 26068415 PMCID： PMC4745136 DOI： 10.1038/ncomms8208
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919