| Literature DB >> 26068194 |
Zhou Xu1, Yong Li, Jing Liu, Nan Wu, Ke Li, Songlei Zhu, Rongli Zhang, Yi Liu.
Abstract
A mild catalyst system for the synthesis of chiral amino alcohols via asymmetric transfer hydrogenation (ATH) of α-phthalimide ketones has been developed by using a chiral Ru-TsDPEN complex as the catalyst in DMF/MeOH at 40 °C. The reaction exhibits high reaction activity and excellent enantioselectivity where up to 96% yield and 99% ee of the product were obtained.Entities:
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Year: 2015 PMID： 26068194 DOI： 10.1039/c5ob00568j
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876