Literature DB >> 26068094

A Chlorin-Based Nanoscale Metal-Organic Framework for Photodynamic Therapy of Colon Cancers.

Kuangda Lu1, Chunbai He1, Wenbin Lin1.   

Abstract

We report here the rational design of the first chlorin-based nanoscale metal-organic framework (NMOF), DBC-UiO, with much improved photophysical properties over the previously reported porphyrin-based NMOF, DBP-UiO. Reduction of the DBP ligands in DBP-UiO to the DBC ligands in DBC-UiO led to a 13 nm red shift and an 11-fold increase in the extinction coefficient of the lowest-energy Q band. While inheriting the crystallinity, stability, porosity, and nanoplate morphology of DBP-UiO, DBC-UiO sensitizes more efficient (1)O2 generation and exhibits significantly enhanced photodynamic therapy (PDT) efficacy on two colon cancer mouse models as a result of its improved photophysical properties. Both apoptosis and immunogenic cell death contributed to killing of cancer cells in DBC-UiO-induced PDT.

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Year:  2015        PMID： 26068094      PMCID： PMC4691355          DOI： 10.1021/jacs.5b04069

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  32 in total

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Review 3.  Nanoparticles in photodynamic therapy: an emerging paradigm.

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Review 4.  Photodynamic therapy of cancer: an update.

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8.  A functional zeolite analogue assembled from metalloporphyrins.

Authors:  Margaret E Kosal; Jun-Hong Chou; Scott R Wilson; Kenneth S Suslick
Journal:  Nat Mater       Date:  2002-10       Impact factor: 43.841

Review 9.  Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer.

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10.  Nanoscale metal-organic framework for highly effective photodynamic therapy of resistant head and neck cancer.

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Journal:  J Am Chem Soc       Date:  2014-11-19       Impact factor: 15.419
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  50 in total

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2.  Nanoscale Metal-Organic Layers for Deeply Penetrating X-ray-Induced Photodynamic Therapy.

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3.  In Vivo Targeting and Positron Emission Tomography Imaging of Tumor with Intrinsically Radioactive Metal-Organic Frameworks Nanomaterials.

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4.  Nanoscale Metal-Organic Frameworks for Phototherapy of Cancer.

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Journal:  Coord Chem Rev       Date:  2017-10-21       Impact factor: 22.315

5.  Ultrafast Relaxation Dynamics of Photoexcited Zinc-Porphyrin: Electronic-Vibrational Coupling.

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Review 6.  Current Advances in Black Phosphorus-Based Drug Delivery Systems for Cancer Therapy.

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Journal:  Adv Sci (Weinh)       Date:  2021-01-15       Impact factor: 16.806

7.  DNA-Assembled Core-Satellite Upconverting-Metal-Organic Framework Nanoparticle Superstructures for Efficient Photodynamic Therapy.

Authors:  Liangcan He; Michael Brasino; Chenchen Mao; Suehyun Cho; Wounjhang Park; Andrew P Goodwin; Jennifer N Cha
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Review 8.  Nanotechnology Strategies To Advance Outcomes in Clinical Cancer Care.

Authors:  Christopher M Hartshorn; Michelle S Bradbury; Gregory M Lanza; Andre E Nel; Jianghong Rao; Andrew Z Wang; Ulrich B Wiesner; Lily Yang; Piotr Grodzinski
Journal:  ACS Nano       Date:  2017-12-22       Impact factor: 15.881

9.  Chlorin-Based Nanoscale Metal-Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy.

Authors:  Kuangda Lu; Chunbai He; Nining Guo; Christina Chan; Kaiyuan Ni; Ralph R Weichselbaum; Wenbin Lin
Journal:  J Am Chem Soc       Date:  2016-09-14       Impact factor: 15.419

10.  Self-Assembly of Porphyrin-Containing Metalla-Assemblies and Cancer Photodynamic Therapy.

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Journal:  Inorg Chem       Date:  2020-01-21       Impact factor: 5.165
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