| Literature DB >> 26067720 |
Toshiki Nokami, Yu Yamane, Shunsuke Oshitani, Jun-ka Kobayashi, Shin-ichiro Matsui, Takashi Nishihara, Hidemitsu Uno1, Shuichi Hayase, Toshiyuki Itoh.
Abstract
Iron salt-catalyzed Friedel-Crafts alkylation of chiral α-aryl alcohols with a trimethylsilyl group was found to proceed with retention of the configuration of the hydroxyl group as a leaving group. The memory of chirality of this system stems from the β-silyl effect of the trimethylsilyl group on the carbocation intermediate.Entities:
Year: 2015 PMID： 26067720 DOI： 10.1021/acs.orglett.5b01582
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005