| Literature DB >> 26067345 |
Ryan L Muetzel1, Sabine E Mous1, Jan van der Ende2, Laura M E Blanken1, Aad van der Lugt3, Vincent W V Jaddoe4, Frank C Verhulst2, Henning Tiemeier5, Tonya White6.
Abstract
Child and adolescent brain development are typically accompanied by marked improvements in a wide range of cognitive abilities. However, limited information is available surrounding the role of white matter in shaping cognitive abilities in children. The current study examined associations between white matter microstructure and cognitive performance in a large sample (n=778) of 6- to 10-year-old children. Results show white matter microstructure is related to non-verbal intelligence and to visuospatial ability, independent of age. Specificity was demonstrated, as white matter associations with visuospatial ability were independent of general intellectual ability. Associations between white matter integrity and cognition were similar in boys and girls. In summary, results demonstrate white matter structure-function associations are present in children, independent of age and broader cognitive abilities. The presence of such associations in the general population is informative for studies examining child psychopathology.Entities:
Keywords: Brain development; Diffusion tensor imaging; MRI; Neuropsychological performance; Population-based imaging
Mesh：
Year: 2015 PMID： 26067345 DOI： 10.1016/j.neuroimage.2015.06.014
Source DB: PubMed Journal: Neuroimage ISSN： 1053-8119 Impact factor: 6.556