| Literature DB >> 26067204 |
Hang Shen1, Jiaqiang Li1, Qing Liu1, Jing Pan1, Ruofeng Huang1, Yan Xiong1,2.
Abstract
An efficient method to synthesize β-ketonitriles from silyl enol ethers by an umploung hypervalent iodine(III)-CN species generated in situ from PhIO/BF3·Et2O/TMSCN has been developed for the first time. This method can be applied to structurally diverse aromatic and aliphatic substrates and further extended to preparation of bioactive compounds like 5-aminopyrazole and 5-aminoisoxazole.Entities:
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Year: 2015 PMID： 26067204 DOI： 10.1021/acs.joc.5b01102
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354