| Literature DB >> 26066910 |
Kazato Inanaga, Takashi Fukuyama, Manabu Kubota, Yuki Komatsu, Hiroyuki Chiba, Akio Kayano, Katsuya Tagami.
Abstract
A novel and efficient method for the Cr(II)-mediated desulfonylation of α-sulfonyl ketone by a Cr-ligand-Mn system has been developed during the course of process research on Halaven (eribulin mesylate). This reaction is dramatically accelerated in the presence of an appropriate bipyridyl-type ligand. This system is applicable to reduction of α-sulfur-substituted ketones. In addition, a Cr-Cp2ZrCl2-Mn catalytic system is also applicable to desulfonylation of α-sulfonyl ketone.Entities:
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Year: 2015 PMID： 26066910 DOI： 10.1021/acs.orglett.5b01497
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005