Lindsey A Sjaarda1, Enrique F Schisterman1, Karen C Schliep1, Torie Plowden1, Shvetha M Zarek1, Edwina Yeung1, Jean Wactawski-Wende1, Sunni L Mumford1. 1. Division of Intramural Population Health Research (L.A.S., E.F.S., K.C.S., T.P., S.M.Z., E.Y., S.L.M.) and Program of Reproductive and Adult Endocrinology (T.P., S.M.Z.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892; and Department of Epidemiology and Environmental Health (J.W.W.), School of Public Health and Health Professions, University at Buffalo, Buffalo, New York 14214.
Abstract
CONTEXT: Diet is proposed to contribute to androgen-related reproductive dysfunction. OBJECTIVE: This study evaluated the association between dietary macronutrient intake, carbohydrate fraction intake, and overall diet quality on androgens and related hormones, including anti-Müllerian hormone (AMH) and insulin, in healthy, regularly menstruating women. DESIGN: This was a prospective cohort study from 2005 and 2007. SETTING: The study was conducted at the University at Buffalo, western New York State, USA. PARTICIPANTS: Participants were 259 eumenorrheic women without a self-reported history of infertility, polycystic ovary syndrome (PCOS), or other endocrine disorder. MAIN OUTCOME MEASURES: A 24-hour dietary recall was administered 4 times per menstrual cycle, and hormones were measured 5 to 8 times per cycle for 1 (n = 9) or 2 (n = 250) cycles per woman (n = 509 cycles). Associations between the dietary intake of carbohydrates (starch, sugar, sucrose, and fiber), macronutrients, overall diet quality and hormones (insulin, AMH, and total and free testosterone), as well as the relationship of dietary intake with occurrences of high total testosterone combined with high AMH (fourth quartile of each), ie, the "PCOS-like phenotype," were assessed. RESULTS: No significant relationships were identified between dietary intake of carbohydrates, percent calories from any macronutrient or overall diet quality (ie, Mediterranean diet score) and relevant hormones (insulin, AMH, and total and free testosterone). Likewise, no significant relationships were identified between dietary factors and the occurrence of a subclinical PCOS-like phenotype. CONCLUSIONS: Despite evidence of a subclinical continuum of a PCOS-related phenotype of elevated androgens and AMH related to sporadic anovulation identified in previous studies, dietary carbohydrate and diet quality do not appear to relate to these subclinical endocrine characteristics in women without overt PCOS.
CONTEXT: Diet is proposed to contribute to androgen-related reproductive dysfunction. OBJECTIVE: This study evaluated the association between dietary macronutrient intake, carbohydrate fraction intake, and overall diet quality on androgens and related hormones, including anti-Müllerian hormone (AMH) and insulin, in healthy, regularly menstruating women. DESIGN: This was a prospective cohort study from 2005 and 2007. SETTING: The study was conducted at the University at Buffalo, western New York State, USA. PARTICIPANTS: Participants were 259 eumenorrheic women without a self-reported history of infertility, polycystic ovary syndrome (PCOS), or other endocrine disorder. MAIN OUTCOME MEASURES: A 24-hour dietary recall was administered 4 times per menstrual cycle, and hormones were measured 5 to 8 times per cycle for 1 (n = 9) or 2 (n = 250) cycles per woman (n = 509 cycles). Associations between the dietary intake of carbohydrates (starch, sugar, sucrose, and fiber), macronutrients, overall diet quality and hormones (insulin, AMH, and total and free testosterone), as well as the relationship of dietary intake with occurrences of high total testosterone combined with high AMH (fourth quartile of each), ie, the "PCOS-like phenotype," were assessed. RESULTS: No significant relationships were identified between dietary intake of carbohydrates, percent calories from any macronutrient or overall diet quality (ie, Mediterranean diet score) and relevant hormones (insulin, AMH, and total and free testosterone). Likewise, no significant relationships were identified between dietary factors and the occurrence of a subclinical PCOS-like phenotype. CONCLUSIONS: Despite evidence of a subclinical continuum of a PCOS-related phenotype of elevated androgens and AMH related to sporadic anovulation identified in previous studies, dietary carbohydrate and diet quality do not appear to relate to these subclinical endocrine characteristics in women without overt PCOS.
Authors: Sunni L Mumford; Enrique F Schisterman; Audrey J Gaskins; Anna Z Pollack; Neil J Perkins; Brian W Whitcomb; Aijun Ye; Jean Wactawski-Wende Journal: Paediatr Perinat Epidemiol Date: 2011-06-14 Impact factor: 3.980
Authors: Audrey J Gaskins; Alisha J Rovner; Sunni L Mumford; Edwina Yeung; Richard W Browne; Maurizio Trevisan; Neil J Perkins; Jean Wactawski-Wende; Enrique F Schisterman Journal: Am J Clin Nutr Date: 2010-10-13 Impact factor: 7.045
Authors: E H Yeung; C Zhang; P S Albert; S L Mumford; A Ye; N J Perkins; J Wactawski-Wende; E F Schisterman Journal: Int J Obes (Lond) Date: 2012-02-07 Impact factor: 5.095
Authors: Meghana D Gadgil; Lawrence J Appel; Edwina Yeung; Cheryl A M Anderson; Frank M Sacks; Edgar R Miller Journal: Diabetes Care Date: 2012-12-05 Impact factor: 19.112
Authors: Ana B Maldonado-Cárceles; Lidia Mínguez-Alarcón; Irene Souter; Audrey J Gaskins; Mariel Arvizu; Paige L Williams; Jennifer B Ford; Jorge E Chavarro Journal: Fertil Steril Date: 2020-07-22 Impact factor: 7.329
Authors: Keewan Kim; Jean Wactawski-Wende; Kara A Michels; Torie C Plowden; Ellen N Chaljub; Lindsey A Sjaarda; Sunni L Mumford Journal: J Nutr Date: 2016-11-23 Impact factor: 4.798
Authors: Keewan Kim; Jean Wactawski-Wende; Kara A Michels; Karen C Schliep; Torie C Plowden; Ellen N Chaljub; Sunni L Mumford Journal: Br J Nutr Date: 2018-04-20 Impact factor: 3.718