CONTEXT: Antidesma bunius L (Phyllanthaceae) is commonly known to local people in North-east Thailand as a medicinal plant. OBJECTIVES: To investigate hypoglycaemic activities of methanolic extract of A. bunius in type 1 diabetes. MATERIALS AND METHODS: A daily dose of A. bunius extract (250 mg/kg body weight) was given orally to alloxan-induced diabetic rats for 28 days. Blood glucose, insulin, TC, TG, amylase, lipase, liver glycogen were analysed. RESULTS: Extract revealed a significant reduction in blood glucose level (80.5%) along with an increase in serum insulin (134%), lipase (90.7%) and liver glycogen level (160%). Also amylase (28.2%) activity, TC (40.2%), and TG (28.8%) levels were significantly decreased when compared with diabetic control rats. A. bunius extract improved the histo-architectural of the β-cells. DISCUSSION AND CONCLUSION: The results suggested that A. bunius extract possess anti-diabetic activity, through the enhancement of hepatic glycogen storage and regeneration of the islet of Langerhans.
CONTEXT: Antidesma bunius L (Phyllanthaceae) is commonly known to local people in North-east Thailand as a medicinal plant. OBJECTIVES: To investigate hypoglycaemic activities of methanolic extract of A. bunius in type 1 diabetes. MATERIALS AND METHODS: A daily dose of A. bunius extract (250 mg/kg body weight) was given orally to alloxan-induced diabeticrats for 28 days. Blood glucose, insulin, TC, TG, amylase, lipase, liver glycogen were analysed. RESULTS: Extract revealed a significant reduction in blood glucose level (80.5%) along with an increase in serum insulin (134%), lipase (90.7%) and liver glycogen level (160%). Also amylase (28.2%) activity, TC (40.2%), and TG (28.8%) levels were significantly decreased when compared with diabetic control rats. A. bunius extract improved the histo-architectural of the β-cells. DISCUSSION AND CONCLUSION: The results suggested that A. bunius extract possess anti-diabetic activity, through the enhancement of hepatic glycogen storage and regeneration of the islet of Langerhans.
Authors: Bince Russo A Crieta; Arvin Paul P Tuaño; Mary Ann O Torio; Jeric C Villanueva; Prince Joseph V Gaban; Katherine Ann T Castillo-Israel Journal: Food Chem (Oxf) Date: 2021-03-25
Authors: Nimra Zafar Siddiqui; Ata Ur Rehman; Waleed Yousuf; Asif Iqbal Khan; Nabeel Ahmed Farooqui; Shizhu Zang; Yi Xin; Liang Wang Journal: Gut Pathog Date: 2022-09-17 Impact factor: 5.324