Qianqian Wang1, Paul Harasymowycz. 1. *Department of Ophthalmology, University of Montreal †Montreal Glaucoma Institute, Montreal, QC, Canada.
Abstract
PURPOSE: To assess the efficacy of collagen cross-linking in the treatment of late-onset bleb leakage. METHODS: A retrospective, interventional case-series. Cross-linking was performed for late-onset bleb leakage after failure of standard medical therapy. Primary outcome is measured by complete resolution of bleb leakage. Secondary outcomes including intraocular pressure and corrected distance visual acuity (CDVA) were documented over 1 year and were analyzed using repeated measure ANOVA. RESULTS: Seven patients underwent cross-linking for bleb leakage between 2012 and 2013. Five (71%) had complete resolution of bleb leakage. Intraocular pressure improved from 3.9±1.0 to 7.4±1.1 mm Hg at 1 to 2 months (P=0.0003) and remained at 9.6±3.0 mm Hg at final visit (P=0.06). The corresponding CDVA also improved from 0.6±0.2 to 0.38±0.37 logMAR (P=0.0069) at 1 to 2 months before stabilizing at 0.38±0.44 (P=0.0021) at 1 year. Two cases (29%) had persistent bleb leakage after treatment. Four patients (57%) had resolved hypotony (≥6 mm Hg) at final visit. No adverse event was reported. CONCLUSIONS: Collagen cross-linking is a noninvasive treatment offering reasonable success rate for filtering bleb leakage, and may spare patients invasive surgical bleb revisions.
PURPOSE: To assess the efficacy of collagen cross-linking in the treatment of late-onset bleb leakage. METHODS: A retrospective, interventional case-series. Cross-linking was performed for late-onset bleb leakage after failure of standard medical therapy. Primary outcome is measured by complete resolution of bleb leakage. Secondary outcomes including intraocular pressure and corrected distance visual acuity (CDVA) were documented over 1 year and were analyzed using repeated measure ANOVA. RESULTS: Seven patients underwent cross-linking for bleb leakage between 2012 and 2013. Five (71%) had complete resolution of bleb leakage. Intraocular pressure improved from 3.9±1.0 to 7.4±1.1 mm Hg at 1 to 2 months (P=0.0003) and remained at 9.6±3.0 mm Hg at final visit (P=0.06). The corresponding CDVA also improved from 0.6±0.2 to 0.38±0.37 logMAR (P=0.0069) at 1 to 2 months before stabilizing at 0.38±0.44 (P=0.0021) at 1 year. Two cases (29%) had persistent bleb leakage after treatment. Four patients (57%) had resolved hypotony (≥6 mm Hg) at final visit. No adverse event was reported. CONCLUSIONS: Collagen cross-linking is a noninvasive treatment offering reasonable success rate for filtering bleb leakage, and may spare patients invasive surgical bleb revisions.
Authors: Bonnie Nga Kwan Choy; Ming Ming Zhu; Jennifer Wei Huen Shum; Wing Lau Ho; Jonathan Cheuk Hung Chan; Alex Lap Ki Ng; Jimmy Shiu Ming Lai Journal: Graefes Arch Clin Exp Ophthalmol Date: 2015-12-21 Impact factor: 3.117
Authors: Diego T Dias; Izabela Almeida; Michele Ushida; Flavio S Lopes; Fábio N Kanadani; Carolina P B Gracitelli; Tiago S Prata Journal: PLoS One Date: 2022-05-26 Impact factor: 3.752