Woong Ju1,2, Hyun Ja Kim3, Susan E Hankinson4,5,6, Immaculata De Vivo4,5, Eunyoung Cho4,7,8. 1. Department of Obstetrics and Gynecology. 2. Medical Research Institute, College of Medicine, Ewha Womans University, Seoul, Republic of Korea. 3. Division of Health and Nutrition Survey, Korea Centers for Disease Control and Prevention, Cheongju-si, Republic of Korea. 4. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. 5. Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115. 6. Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA. 7. Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI. 8. Department of Epidemiology, Brown School of Public Health, Providence, RI.
Abstract
BACKGROUND: Epidemiologic studies have found that overall obesity is positively related to endometrial cancer (EC) risk. However, data assessing the association between body fat distribution and risk of EC are still limited. METHODS: We followed 51,948 women who first reported waist circumference (WC) and hip circumference in 1986 in the Nurses' Health Study. Waist-to-hip ratio (WHR) was calculated. RESULTS: During 24 years of follow-up, 449 incident invasive EC cases were diagnosed. In a multivariate analysis without adjusting for body mass index (BMI), the relative risks (RRs) for EC comparing extreme categories were 2.44 (95% confidence interval [CI] 1.72-3.45) for WC and 1.69 (95% CI=1.20-2.40) for WHR. However, after adjustment of BMI, those positive associations were substantially attenuated and no longer significant; RR=1.08 (95% CI=0.69-1.67) for WC and 1.15 (95% CI=0.81-1.64) for WHR, respectively. CONCLUSION: In our prospective cohort study, we found no independent association between body fat distribution and the risk of EC after adjustment for BMI.
BACKGROUND: Epidemiologic studies have found that overall obesity is positively related to endometrial cancer (EC) risk. However, data assessing the association between body fat distribution and risk of EC are still limited. METHODS: We followed 51,948 women who first reported waist circumference (WC) and hip circumference in 1986 in the Nurses' Health Study. Waist-to-hip ratio (WHR) was calculated. RESULTS: During 24 years of follow-up, 449 incident invasive EC cases were diagnosed. In a multivariate analysis without adjusting for body mass index (BMI), the relative risks (RRs) for EC comparing extreme categories were 2.44 (95% confidence interval [CI] 1.72-3.45) for WC and 1.69 (95% CI=1.20-2.40) for WHR. However, after adjustment of BMI, those positive associations were substantially attenuated and no longer significant; RR=1.08 (95% CI=0.69-1.67) for WC and 1.15 (95% CI=0.81-1.64) for WHR, respectively. CONCLUSION: In our prospective cohort study, we found no independent association between body fat distribution and the risk of EC after adjustment for BMI.
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