What Is the Optimal Timing of Bowel Preparation for Video Capsule Endoscopy?

See "A Single-Center Randomized Controlled Trial Evaluating Timing of Preparation for Capsule Enteroscopy" by Katherine R. Black, Wiley Truss, Cynthia I. Joiner, Shajan Peter and Frederick H. Weber Jr, on page 234-238

Bowel preparation prior to video capsule endoscopy (VCE) is as essential as bowel preparation prior to colonoscopy, since several factors, such as food material, air bubbles in the small bowel and delayed gastric and small bowel transit time (SBTT) influence the small bowel visualization quality (SBVQ), diagnostic yield (DY), and completion rate (CR). The 2009 European Society of Gastrointestinal Endoscopy guidelines advise that purgative bowel preparations enhance the DY of a small bowel examination using VCE and do not affect the VCE CR (category of evidence 2a; grade of recommendation B).1

According to the 2013 Korean guidelines from the Korean Gut Image Study Group,2 bowel preparation with polyethylene glycol (PEG) solution enhances SBVQ and DY, but has no effect on cecal CR. Bowel preparation with 2 L of PEG solution is similar to that with 4 L of PEG in terms of the SBVQ, DY, and CR of VCE. Bowel preparation with fasting or PEG solution combined with simethicone enhances the SBVQ, but does not affect the CR of VCE. Bowel preparation with prokinetics does not enhance the SBVQ, DY, or CR of VCE. A 2 L PEG-based purge, administered the day before the procedure, is the most widely practiced preparation regimen.3 To date, there is no consensus regarding the optimal timing of bowel preparation for VCE.4

Black et al.5 conducted a single-center randomized controlled trial evaluating preparation for VCE. Thirty-four patients were randomized prospectively into two equal groups according to the timing of intestinal lavage (2 L of PEG). Group A had the intestinal lavage over 2 hours, beginning 14 hours before the scheduled VCE, and group B began ingestion 4 hours prior to the study. The results regarding mucosal abnormalities (77% vs. 82%, p=not significant [NS]) and DY (47% vs. 53%, p=NS) were similar for both groups. There was no significant association between the quality and timing of small bowel preparation. The day before intestinal lavage was similar to same-day preparation with respect to overall preparation quality, CR, SBTT, frequency of identified mucosal abnormalities, and overall DY.

To the best of our knowledge, this is the first study to consider the timing of bowel preparation for VCE and is the first to assess the optimal 'timing' for initiating intestinal lavage in VCE. As mentioned, timing of purgative administration may be a critical factor for visualization and VCE CRs. Most purgative studies have administered purgatives the day prior to the VCE.6,7,8,9,10 A Korean study compared fasting for 12 hours and receiving 2 or 4 L of PEG 4 hours prior to PEG. It showed that bowel preparation with PEG resulted in a better image quality than fasting alone,11 but no significant difference was observed between 2 and 4 L of PEG.

With respect to bowel preparation for the colonoscopy, the quality of bowel preparation is significantly better when there is a shorter time between bowel preparation and the start of colonoscopy.12 A shorter (<8 hours) interval between the end of bowel preparation and the start of colonoscopy yielded better bowel cleansing than a longer (>8 hours) interval.13 Since the small intestine is anatomically proximal, the authors hypothesized that a similar lavage timing concept would be advantageous for VCE small intestinal visualization and perhaps transit. The overall evidence base for small bowel VCE is immature and validated scales for quality of cleansing are not yet available.4 One of the issues for bowel preparation of VCE is that the distal segment of the small intestine should be improved. However, there was no significant difference between the two groups (day-before VCE vs. 4 hours prior to VCE) in this study.5

Recently, different kinds of bowel preparation such as PEG, PEG plus ascorbic acid, sodium picosulfate and phosphate (NaP) have become available.14 NaP is not generally recommended for bowel cleansing due to the potential for renal damage and other adverse events. However, the use of NaP is acceptable in patients for whom PEG or sodium picosulfate is ineffective or not tolerated.4 There was no published evidence to support the use of sodium picosulfate; however, it is used in some units. Anecdotal evidence suggests that it is not as effective as PEG.4 For each of these agents, a consensus should be reached regarding the optimal timing of bowel preparation.

The main limitation of this study is that the number of patients (n=34) is not sufficient for generalization to actual practice. Therefore, a large, multicenter randomized controlled trial is needed to clarify the optimal timing of bowel preparation for VCE. Guidelines for timing of bowel preparation should be made in the near future.