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Literature DB >> 2606479

The gene encoding the human preproacrosin (ACR) maps to the q13-qter region on chromosome 22.

I M Adham¹, K H Grzeschik, A H Geurts van Kessel, W Engel.

Abstract

Human proproacrosin is specified by a single gene (ACR). Using a series of human-rodent somatic cell hybrids containing variant complements of human chromosomes, the preproacrosin gene was found to cosegregate with human chromosome 22. Somatic cell hybrids containing translocation chromosomes carrying parts of chromosome 22 were used to locate the preproacrosin gene to the region 22q13-22qter. By probing the DNA of 82 individuals, a restriction fragment length polymorphism was found with SstI in 14 cases.

Entities: Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2606479 DOI： 10.1007/bf00210672

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

14 in total

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Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

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Journal: Somat Cell Mol Genet Date: 1984-07

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Journal: Cytogenet Cell Genet Date: 1980

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Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1984-02 Impact factor: 3.365

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Authors: G Camerino; K H Grzeschik; M Jaye; H De La Salle; P Tolstoshev; J P Lecocq; R Heilig; J L Mandel
Journal: Proc Natl Acad Sci U S A Date: 1984-01 Impact factor: 11.205

6. Amplification of the c-myc oncogene in a subpopulation of human small cell lung cancer.

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Journal: Cancer Res Date: 1985-04 Impact factor: 12.701

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Authors: B U Zabel; S L Naylor; K H Grzeschik; A Y Sakaguchi
Journal: Somat Cell Mol Genet Date: 1984-01

8. Molecular cloning of human preproacrosin cDNA.

Authors: I M Adham; U Klemm; W M Maier; W Engel
Journal: Hum Genet Date: 1990-01 Impact factor: 4.132

9. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia.

Authors: A de Klein; A G van Kessel; G Grosveld; C R Bartram; A Hagemeijer; D Bootsma; N K Spurr; N Heisterkamp; J Groffen; J R Stephenson
Journal: Nature Date: 1982-12-23 Impact factor: 49.962

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Journal: J Biol Chem Date: 1977-03-25 Impact factor: 5.157

6 in total

1. Partial monosomy for chromosome 22 in a patient with del(22)(pter----q13.1::q13.33----qter).

Authors: D R Romain; J Goldsmith; H Cairney; L M Columbano-Green; R H Smythe; R G Parfitt
Journal: J Med Genet Date: 1990-09 Impact factor: 6.318

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Journal: Mamm Genome Date: 1992 Impact factor: 2.957

6. Molecular characterisation of the 22q13 deletion syndrome supports the role of haploinsufficiency of SHANK3/PROSAP2 in the major neurological symptoms.

Authors: H L Wilson; A C C Wong; S R Shaw; W-Y Tse; G A Stapleton; M C Phelan; S Hu; J Marshall; H E McDermid
Journal: J Med Genet Date: 2003-08 Impact factor: 6.318