Literature DB >> 26064388

Association of genetic polymorphisms in HTR3A and HTR3E with diarrhea predominant irritable bowel syndrome.

Qiao-Yan Gu1, Jun Zhang2, Yi-Chao Feng3, Guang-Rong Dai3, Wei-Ping Du3.   

Abstract

OBJECTIVE: The present study aims to investigate the relationship between genetic polymorphisms in HTR3A and HTR3E and diarrhea predominant irritable bowel syndrome (D-IBS) in a Chinese population.
METHODS: We enrolled 500 D-IBS patients and 500 age- and sex-matched healthy control subjects to detect the genotypes in HTR3A and HTR3B gene by using of PCR-RFLP method.
RESULTS: There were significant difference between the D-IBS patients and the health control subjects in the distribution of genotype and allele of rs1062613 in HTR3A gene. As regarding rs62625044 in HTR3E gene, we found there was a significant different between the case and the control group in the distribution of GA genotype and A allele in female but not in male.
CONCLUSION: The present study suggested that there are associations of D-IBS risk with genetic polymorphisms in HTR3A and HTR3E.

Entities:  

Keywords:  Diarrhea predominant irritable bowel syndrome; HTR3A; HTR3E; gene; polymorphism

Year:  2015        PMID： 26064388      PMCID： PMC4443222     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


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  7 in total

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