Wei Gao1, Kaijing Wang2, Zhe Zhu1, Bing Lu1, Xiaogang Zhou1, Zhuqing Zhou1, Yao Yang1, Jiangfan Zhu1. 1. Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120, China. 2. Department of General Surgery, Shanghai Tongji Hospital, Tongji University School of Medicine Shanghai, 200065, China.
Abstract
AIM: To study the impact of sleeve gastrectomy plus side-to-side jejunoileal anastomosis on weight loss and the remission of type 2 diabetes mellitus. METHODS: Thirty-three 7 weeks old male Zucker diabetic fatty rats were randomized into three groups: sleeve gastrectomy plus side-to-side jejunoileal anastomosis (JI-SG group), sleeve gastrectomy (SG group), sham surgery (Control group). RESULTS: The weight of rats in JI-SG group and SG group was significantly lower than control group at 2 weeks postoperatively, and body weight in JI-SG group was lower than SG group since 4 week postoperatively. The blood Glucose was significantly improved for both JI-SG group and SG group, and increased in Control group at 2 weeks after surgery. The serum ghrelin level of rats in JI-SG, SG group was significantly decreased, but without difference between two groups; compared with that preoperatively, the GLP-1 level of rats in JI-SG group was significantly higher at 12 weeks postoperatively; SG group and SO group had no difference in the GLP-1. The serum insulin level in rats was also decreased in JI-SG group and SG group at 6 weeks postoperatively, and plasma insulin level in JI-SG group was significantly lower than those in the SG group at 12 weeks postoperatively. CONCLUSIONS: JI-SG is superior to SG as the treatment of type 2 diabetes mellitus and weight control in obese diabetic rodents.
AIM: To study the impact of sleeve gastrectomy plus side-to-side jejunoileal anastomosis on weight loss and the remission of type 2 diabetes mellitus. METHODS: Thirty-three 7 weeks old male Zucker diabetic fatty rats were randomized into three groups: sleeve gastrectomy plus side-to-side jejunoileal anastomosis (JI-SG group), sleeve gastrectomy (SG group), sham surgery (Control group). RESULTS: The weight of rats in JI-SG group and SG group was significantly lower than control group at 2 weeks postoperatively, and body weight in JI-SG group was lower than SG group since 4 week postoperatively. The blood Glucose was significantly improved for both JI-SG group and SG group, and increased in Control group at 2 weeks after surgery. The serum ghrelin level of rats in JI-SG, SG group was significantly decreased, but without difference between two groups; compared with that preoperatively, the GLP-1 level of rats in JI-SG group was significantly higher at 12 weeks postoperatively; SG group and SO group had no difference in the GLP-1. The serum insulin level in rats was also decreased in JI-SG group and SG group at 6 weeks postoperatively, and plasma insulin level in JI-SG group was significantly lower than those in the SG group at 12 weeks postoperatively. CONCLUSIONS: JI-SG is superior to SG as the treatment of type 2 diabetes mellitus and weight control in obese diabetic rodents.
Entities:
Keywords:
Side to side jejunoileal anastomosis; sleeve gastrectomy; type 2 diabetes; zucker diabetic fatty rat
Authors: Philip R Schauer; Deepak L Bhatt; John P Kirwan; Kathy Wolski; Stacy A Brethauer; Sankar D Navaneethan; Ali Aminian; Claire E Pothier; Esther S H Kim; Steven E Nissen; Sangeeta R Kashyap Journal: N Engl J Med Date: 2014-03-31 Impact factor: 91.245
Authors: Tian Tian Wang; San Yuan Hu; Hai Dong Gao; Guang Yong Zhang; Chong Zhong Liu; Jin Bo Feng; Eldo E Frezza Journal: Ann Surg Date: 2008-06 Impact factor: 12.969
Authors: Lars Sjöström; Markku Peltonen; Peter Jacobson; Sofie Ahlin; Johanna Andersson-Assarsson; Åsa Anveden; Claude Bouchard; Björn Carlsson; Kristjan Karason; Hans Lönroth; Ingmar Näslund; Elisabeth Sjöström; Magdalena Taube; Hans Wedel; Per-Arne Svensson; Kajsa Sjöholm; Lena M S Carlsson Journal: JAMA Date: 2014-06-11 Impact factor: 56.272
Authors: Anita P Courcoulas; Nicholas J Christian; Steven H Belle; Paul D Berk; David R Flum; Luis Garcia; Mary Horlick; Melissa A Kalarchian; Wendy C King; James E Mitchell; Emma J Patterson; John R Pender; Alfons Pomp; Walter J Pories; Richard C Thirlby; Susan Z Yanovski; Bruce M Wolfe Journal: JAMA Date: 2013-12-11 Impact factor: 56.272
Authors: Dimitrios J Pournaras; Alan Osborne; Simon C Hawkins; Royce P Vincent; David Mahon; Paul Ewings; Mohammad A Ghatei; Stephen R Bloom; Richard Welbourn; Carel W le Roux Journal: Ann Surg Date: 2010-12 Impact factor: 12.969