Peng Shao1, Da-Jun Qu2, Rui-Ying Song3, Ming-Lu Chen4, Li-Hua Wang5. 1. Department of Rehabilitation Medicine, Yantaishan Hospital Yantai 264000, China. 2. Department of Drug Purchase, Haiyang People's Hospital Haiyang 265100, China. 3. Department of Otolaryngology, Yuhuangding Hospital Affiliated to Qingdao University Yantai 264000, China. 4. Department of Nuclear Radiology, Shandong Province Tumor Hospital Jinnan 250021, China. 5. Department of Pediatrics, Haiyang People's Hospital Haiyang 265100, China.
Abstract
OBJECTIVE: The present study aims to evaluate the relation between PON1 L55M polymorphism and ischemic stroke by a meta-analysis method. METHODS: English and Chinese databases were retrieved to find qualified studies; a random or fixed effects model was used to merge the odds ratio (OR); Q test was used to assess the heterogeneity among studies, and Egger's test and funnel plot were used for the assessment of publication bias. RESULTS: 14 studies were included in the meta-analysis; in total populations, there was no association between PON1 gene L55M polymorphism and ischemic stroke in additive, dominant, and recessive model, respectively. Furthermore, we did not found associations between L55M and ischemic stroke in Asian or Caucasian population. CONCLUSION: Available evidences suggested that L55M polymorphism had no effect on the risk of ischemic stroke. However, this conclusion needs further validation by larger sample and well-designed studies.
OBJECTIVE: The present study aims to evaluate the relation between PON1L55M polymorphism and ischemic stroke by a meta-analysis method. METHODS: English and Chinese databases were retrieved to find qualified studies; a random or fixed effects model was used to merge the odds ratio (OR); Q test was used to assess the heterogeneity among studies, and Egger's test and funnel plot were used for the assessment of publication bias. RESULTS: 14 studies were included in the meta-analysis; in total populations, there was no association between PON1 gene L55M polymorphism and ischemic stroke in additive, dominant, and recessive model, respectively. Furthermore, we did not found associations between L55M and ischemic stroke in Asian or Caucasian population. CONCLUSION: Available evidences suggested that L55M polymorphism had no effect on the risk of ischemic stroke. However, this conclusion needs further validation by larger sample and well-designed studies.
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