Literature DB >> 2606337

Food intake suppressant effect of baclofen in rats.

M R Zarrindast1, T Hosseini-Nia, S Allah-Maddadi.   

Abstract

1. Baclofen given intraperitoneally (i.p.) to rats caused a dose-dependent decrease in food intake. 2. Bicuculline or picrotoxin (GABAA-antagonist) and methergoline (5-HT antagonist) decreased the anorectic effect of baclofen. 3. Pimozide (dopamine receptor blocker), phenoxybenzamine and propranolol (alpha and beta adrenergic blockers) did not diminish the baclofen effect, but even increased the anorexia induced by the drug. 4. It can be postulated that, at least partially, GABAA receptor mechanism, GABA-5HT receptor complex and/or 5-HT mechanism may be involved in baclofen induced anorexia.

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Year:  1989        PMID： 2606337     DOI： 10.1016/0306-3623(89)90110-9

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  6 in total

Review 1.  Pharmacological approaches for the treatment of obesity.

Authors:  José-Antonio Fernández-López; Xavier Remesar; Màrius Foz; Marià Alemany
Journal:  Drugs       Date:  2002       Impact factor: 9.546

2.  Baclofen reduces fat intake under binge-type conditions.

Authors:  Ariel Buda-Levin; Francis H E Wojnicki; Rebecca L Corwin
Journal:  Physiol Behav       Date:  2005-09-15

3.  Effects of baclofen on operant performance for food pellets and vegetable shortening after a history of binge-type behavior in non-food deprived rats.

Authors:  F H E Wojnicki; D C S Roberts; R L W Corwin
Journal:  Pharmacol Biochem Behav       Date:  2006-06-19       Impact factor: 3.533

4.  Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment.

Authors:  Mehdi Farokhnia; Mikela B Sheskier; Mary R Lee; April N Le; Erick Singley; Sofia Bouhlal; Timmy Ton; Zhen Zhao; Lorenzo Leggio
Journal:  Neuropharmacology       Date:  2018-04-14       Impact factor: 5.250

5.  GABA(B) receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice.

Authors:  Joyce Besheer; Veronique Lepoutre; Clyde W Hodge
Journal:  Psychopharmacology (Berl)       Date:  2004-02-19       Impact factor: 4.530

6.  Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride intake during cell dehydration.

Authors:  Everton H Kimura; Lisandra B De Oliveira; José V Menani; João C Callera
Journal:  Behav Brain Funct       Date:  2013-05-03       Impact factor: 3.759
  6 in total

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