BACKGROUND: The asthmatic patient's respiratory tract deposition of HFA fluticasone (Flovent HFA(™)) has not been established. There is a known large particle size difference with another commercial inhaled HFA steroid (QVAR(™)). This study compared the 2D and 3D respiratory tract deposition of each inhaled steroid. METHODS: This study was an open label, crossover study in eight patients diagnosed with asthma. The regional respiratory and oropharyngeal deposition of the two steroids were compared and contrasted using planar and SPECT imaging following delivery of the (99m)Tc-radiolabeled drug in each product. The SPECT images were merged with computed tomography images to quantify regional deposition within the patients. RESULTS: Two-dimensional (2D) planar images indicated that 24% of the Flovent HFA dose and 55% of the QVAR dose deposited in the lungs. 2D oropharyngeal deposition indicated that 75% of the Flovent HFA dose was deposited in the oropharynx, while 42% of the QVAR dose deposited in the oropharynx. Three-dimensional (3D) SPECT data indicated that 22% of the Flovent HFA dose and 53% of the QVAR dose deposited in the lungs. 3D oropharyngeal and gut deposition indicated 78% of the Flovent HFA dose was deposited in the oropharynx, while 47% of the QVAR dose deposited in the oropharynx. The increased lung deposition and decreased oropharynx deposition for both 2D and 3D image data of QVAR were statistically different from Flovent HFA. CONCLUSIONS: QVAR exhibited a significant increase in lung delivery compared to Flovent HFA. Conversely, QVAR delivered a significantly lower dose to the oropharynx than Flovent HFA. The findings were presumed to be driven by the smaller particle size of QVAR (0.7 microns MMAD) compared with Flovent HFA (2.0 microns MMAD).
BACKGROUND: The asthmatic patient's respiratory tract deposition of HFAfluticasone (Flovent HFA(™)) has not been established. There is a known large particle size difference with another commercial inhaled HFAsteroid (QVAR(™)). This study compared the 2D and 3D respiratory tract deposition of each inhaled steroid. METHODS: This study was an open label, crossover study in eight patients diagnosed with asthma. The regional respiratory and oropharyngeal deposition of the two steroids were compared and contrasted using planar and SPECT imaging following delivery of the (99m)Tc-radiolabeled drug in each product. The SPECT images were merged with computed tomography images to quantify regional deposition within the patients. RESULTS: Two-dimensional (2D) planar images indicated that 24% of the Flovent HFA dose and 55% of the QVAR dose deposited in the lungs. 2D oropharyngeal deposition indicated that 75% of the Flovent HFA dose was deposited in the oropharynx, while 42% of the QVAR dose deposited in the oropharynx. Three-dimensional (3D) SPECT data indicated that 22% of the Flovent HFA dose and 53% of the QVAR dose deposited in the lungs. 3D oropharyngeal and gut deposition indicated 78% of the Flovent HFA dose was deposited in the oropharynx, while 47% of the QVAR dose deposited in the oropharynx. The increased lung deposition and decreased oropharynx deposition for both 2D and 3D image data of QVAR were statistically different from Flovent HFA. CONCLUSIONS:QVAR exhibited a significant increase in lung delivery compared to Flovent HFA. Conversely, QVAR delivered a significantly lower dose to the oropharynx than Flovent HFA. The findings were presumed to be driven by the smaller particle size of QVAR (0.7 microns MMAD) compared with Flovent HFA (2.0 microns MMAD).
Authors: David B Price; Gene Colice; Elliot Israel; Nicolas Roche; Dirkje S Postma; Theresa W Guilbert; Willem M C van Aalderen; Jonathan Grigg; Elizabeth V Hillyer; Victoria Thomas; Richard J Martin Journal: ERJ Open Res Date: 2016-05-26
Authors: Maria Paula Henao; Jennifer L Kraschnewski; Matthew D Bolton; Faoud Ishmael; Timothy Craig Journal: Int J Environ Res Public Health Date: 2020-10-06 Impact factor: 3.390
Authors: Omar S Usmani; Nicolas Roche; Martin Jenkins; Neda Stjepanovic; Peter Mack; Wilfried De Backer Journal: Int J Chron Obstruct Pulmon Dis Date: 2021-01-18
Authors: Omar Usmani; Nicolas Roche; Ezanul Wahab; Samuel Israel; Martin Jenkins; Roopa Trivedi; Paul Dorinsky; Magnus Aurivillius Journal: Respir Res Date: 2021-10-07
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Authors: Omar S Usmani; Nicola Scichilone; Benjamin Mignot; Dennis Belmans; Cedric Van Holsbeke; Jan De Backer; Roberta De Maria; Erika Cuoghi; Eva Topole; George Georges Journal: Int J Chron Obstruct Pulmon Dis Date: 2020-10-07