Literature DB >> 2606144

Localization of interleukin 6 mRNA in human tonsils by in situ hybridization.

A Bosseloir1, E L Hooghe-Peters, E Heinen, N Cormann, C Kinet-Denoël, L Vanhaelst, L Simar.   

Abstract

We have investigated which areas produce interleukin 6 (IL 6) in human tonsils. This growth factor is required for the terminal differentiation of B lymphocytes into plasmocytes. Using 35S-labeled IL 6 cDNA we demonstrated IL 6 gene expression over various areas of the tonsils, with consistent exception of the follicles, by in situ hybridization. It is, therefore, proposed that B cells are stimulated during their migration out of the follicles.

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Year:  1989        PMID： 2606144     DOI： 10.1002/eji.1830191230

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  7 in total

1.  Interleukin-6, but not interleukin-4, is expressed by Reed-Sternberg cells in Hodgkin's disease with or without histologic features of Castleman's disease.

Authors:  S M Hsu; S S Xie; P L Hsu; J A Waldron
Journal:  Am J Pathol       Date:  1992-07       Impact factor: 4.307

2.  Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells.

Authors:  Jacob M van Laar; Marc Melchers; Y K Onno Teng; Boris van der Zouwen; Rozbeh Mohammadi; Randy Fischer; Leonid Margolis; Wendy Fitzgerald; Jean-Charles Grivel; Ferdinand C Breedveld; Peter E Lipsky; Amrie C Grammer
Journal:  Am J Pathol       Date:  2007-08-09       Impact factor: 4.307

3.  Detection of rare RNA sequences by single-enzyme in situ reverse transcription-polymerase chain reaction. High-resolution analyses of interleukin-6 mRNA in paraffin sections of lymph nodes.

Authors:  J Peters; M Krams; H H Wacker; A Carstens; D Weisner; K Hamann; M Menke; D Harms; R Parwaresch
Journal:  Am J Pathol       Date:  1997-02       Impact factor: 4.307

4.  Inducible nitric oxide synthase and proinflammatory cytokine expression by human keratinocytes during acute urticaria.

Authors:  P A Bécherel; O Chosidow; L Le Goff; C Francès; P Debré; M D Mossalayi; M Arock
Journal:  Mol Med       Date:  1997-10       Impact factor: 6.354

5.  Localization of IFN-gamma and IL-6 mRNA in murine intestine by in situ hybridization.

Authors:  S Bao; S Goldstone; A J Husband
Journal:  Immunology       Date:  1993-12       Impact factor: 7.397

6.  Functional heterogeneity and pathogenic significance of interleukin-6 in B-cell lymphomas.

Authors:  S M Hsu; S S Xie; J A Waldron
Journal:  Am J Pathol       Date:  1992-10       Impact factor: 4.307

7.  Increased interleukin-6 (IL-6) production in a young child with clinical and pathologic features of multicentric Castleman's disease.

Authors:  M C Kinney; D S Hummell; P M Villiger; A Hourigan; L Rollins-Smith; A D Glick; A R Lawton
Journal:  J Clin Immunol       Date:  1994-11       Impact factor: 8.317
  7 in total

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