Literature DB >> 2606143

Human interleukin 2 (IL 2) receptor beta chain allows transduction of IL 2-induced proliferation signal(s) in a murine cell line.

T Doi1, M Hatakeyama, S Minamoto, T Kono, H Mori, T Taniguchi.   

Abstract

Interleukin 2 (IL 2) delivers cell growth signal by virtue of its interaction with the high-affinity receptor complex, which consists of two distinct IL 2-binding molecules: the IL 2 receptor alpha (IL 2R alpha) and beta (IL 2R beta) chains. Unlike many known growth factor receptors, neither of the IL 2R chains seems to contain a tyrosine kinase domain. In this report, we have shown that the human IL 2R beta chain expressed in a murine IL 3-dependent, non-lymphoid cell line can transduce IL 2-induced cell proliferation signal(s) in combination with the autologous mouse IL 2R alpha chain. This observation should provide a tool to dissect IL 2-induced signal transduction pathway in lymphoid and non-lymphoid cells.

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Year:  1989        PMID： 2606143     DOI： 10.1002/eji.1830191229

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  11 in total

1.  A critical role for cyclin C in promotion of the hematopoietic cell cycle by cooperation with c-Myc.

Authors:  Z J Liu; T Ueda; T Miyazaki; N Tanaka; S Mine; Y Tanaka; T Taniguchi; H Yamamura; Y Minami
Journal:  Mol Cell Biol       Date:  1998-06       Impact factor: 4.272

2.  The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment.

Authors:  H Shibuya; M Yoneyama; Y Nakamura; H Harada; M Hatakeyama; S Minamoto; T Kono; T Doi; R White; T Taniguchi
Journal:  Nucleic Acids Res       Date:  1990-07-11       Impact factor: 16.971

3.  Interleukin 2 receptor beta chain expressed in an oligodendroglioma line binds interleukin 2 and delivers growth signal.

Authors:  Y Okamoto; S Minamoto; K Shimizu; H Mogami; T Taniguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

4.  Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement of tyrosine kinase(s) other than p56lck.

Authors:  H Otani; J P Siegel; M Erdos; J R Gnarra; M B Toledano; M Sharon; H Mostowski; M B Feinberg; J H Pierce; W J Leonard
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

Review 5.  Protein kinase C in IL-2 signal transduction.

Authors:  Y Lu; J P Durkin
Journal:  Immunol Res       Date:  1997       Impact factor: 2.829

6.  CD4 and CD8 regulate interleukin 2 responses of T cells.

Authors:  K Takahashi; M Nakata; T Tanaka; H Adachi; H Nakauchi; H Yagita; K Okumura
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

7.  Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling.

Authors:  A Kawahara; Y Minami; T Taniguchi
Journal:  Mol Cell Biol       Date:  1994-08       Impact factor: 4.272

8.  Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

Authors:  N Kobayashi; T Kono; M Hatakeyama; Y Minami; T Miyazaki; R M Perlmutter; T Taniguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

9.  Intermediate- and high-affinity interleukin-2 receptors expressed in an IL-4-dependent T-cell line induce different signals.

Authors:  A Rebollo; A Silva
Journal:  Immunology       Date:  1993-10       Impact factor: 7.397

10.  Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment.

Authors:  Chia-Lin Hsu; Kazu Kikuchi; Motonari Kondo
Journal:  Blood       Date:  2007-05-29       Impact factor: 22.113
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