Adnan I Qureshi1, Morad Chughtai2, Tokpagnan Oscar Loua3, Jean Pe Kolie4, Hadja Fatou Sikhe Camara5, Muhammad Fawad Ishfaq2, Cheikh Tidane N'Dour6, Kezely Beavogui7. 1. Zeenat Qureshi Clinical Neuroscience Institute, Donka National Hospital, Conakry, Guinea Zeenat Qureshi Stroke Institute, St Cloud, Minnesota. 2. Rubin Institute of Advanced Orthopedics, Sinai Hospital, Baltimore, Maryland. 3. Department of Neurosurgery, Donka National Hospital. 4. Department of Visceral Surgery, China-Guinea Friendship Hospital. 5. Office of Directress and General Manager, Donka National Hospital, Conakry, Guinea. 6. Department of Infectious Diseases, University of Cheikh Anta Diop of Dakar, Sengal. 7. Department of Neurosurgery, Donka National Hospital National Program to Combat Trauma and Violence in Guinea, Ministry of Health and World Health Organization, Conakry.
Abstract
BACKGROUND: There is a paucity of data regarding health consequences of Ebola virus disease among survivors. METHODS: We surveyed 105 Ebola virus disease survivors postdischarge from an Ebola treatment unit in Guinea using a standard data collection form. Patients rated recovery as the percentage of improvement in functional status, where 0% represents "unable to perform" and 100% represents "able to perform at prior level." RESULTS: The mean ± standard deviation time interval between hospital discharge and administration of questionnaire was 103.5 ± 47.9 days in 105 survivors. Anorexia was reported by 103 patients, with varying severity levels: mild (n = 33), moderate (n = 65), or severe (n = 5). Reported pain according to site was chest (30.7%), joint (86.7%), muscle (26.7%), and back (45.7%), among others. Recovery in functional status was graded as mild (10%-30%) (n = 2 [1.9%]), moderate (40%-70%) (n = 52 [50.0%]), and excellent (80%-100%) (n = 50 [48.1%]). Severity of arthralgia (R(2) = 0.09; P = .008) was directly associated with lower recovery in functional status in multivariate analysis. CONCLUSIONS: Ebola virus disease survivors frequently reported anorexia and arthralgia. Severity of arthralgia was related to lower functional recovery. There may be a role for focused screening and intervention for symptoms identified in this study of survivors.
BACKGROUND: There is a paucity of data regarding health consequences of Ebola virus disease among survivors. METHODS: We surveyed 105 Ebola virus disease survivors postdischarge from an Ebola treatment unit in Guinea using a standard data collection form. Patients rated recovery as the percentage of improvement in functional status, where 0% represents "unable to perform" and 100% represents "able to perform at prior level." RESULTS: The mean ± standard deviation time interval between hospital discharge and administration of questionnaire was 103.5 ± 47.9 days in 105 survivors. Anorexia was reported by 103 patients, with varying severity levels: mild (n = 33), moderate (n = 65), or severe (n = 5). Reported pain according to site was chest (30.7%), joint (86.7%), muscle (26.7%), and back (45.7%), among others. Recovery in functional status was graded as mild (10%-30%) (n = 2 [1.9%]), moderate (40%-70%) (n = 52 [50.0%]), and excellent (80%-100%) (n = 50 [48.1%]). Severity of arthralgia (R(2) = 0.09; P = .008) was directly associated with lower recovery in functional status in multivariate analysis. CONCLUSIONS:Ebola virus disease survivors frequently reported anorexia and arthralgia. Severity of arthralgia was related to lower functional recovery. There may be a role for focused screening and intervention for symptoms identified in this study of survivors.
Authors: Sam Tozay; William A Fischer; David A Wohl; Kayla Kilpatrick; Fei Zou; Edwina Reeves; Korto Pewu; Jean DeMarco; Amy James Loftis; Katie King; Donald Grant; John Schieffelin; Galakpai Gorvego; Henrietta Johnson; Tonia Conneh; Gerald Williams; Julie A E Nelson; David Hoover; Darrius McMillian; Carson Merenbloom; Darrell Hawks; Karine Dube; Jerry Brown Journal: Clin Infect Dis Date: 2020-10-23 Impact factor: 9.079
Authors: Michael C Sneller; Cavan Reilly; Moses Badio; Rachel J Bishop; Allen O Eghrari; Soka J Moses; Kumblytee L Johnson; Dehkontee Gayedyu-Dennis; Lisa E Hensley; Elizabeth S Higgs; Avindra Nath; Kaylie Tuznik; Justin Varughese; Kenneth S Jensen; Bonnie Dighero-Kemp; James D Neaton; H Clifford Lane; Mosoka P Fallah Journal: N Engl J Med Date: 2019-03-07 Impact factor: 91.245
Authors: Jessica G Shantha; Ian Crozier; Brent R Hayek; Beau B Bruce; Catherine Gargu; Jerry Brown; John Fankhauser; Steven Yeh Journal: Ophthalmology Date: 2016-11-30 Impact factor: 12.079
Authors: Robin Burk; Laura Bollinger; Joshua C Johnson; Jiro Wada; Sheli R Radoshitzky; Gustavo Palacios; Sina Bavari; Peter B Jahrling; Jens H Kuhn Journal: FEMS Microbiol Rev Date: 2016-06-05 Impact factor: 16.408
Authors: John G Mattia; Mathew J Vandy; Joyce C Chang; Devin E Platt; Kerry Dierberg; Daniel G Bausch; Tim Brooks; Sampha Conteh; Ian Crozier; Robert A Fowler; Amadu P Kamara; Cindy Kang; Srividya Mahadevan; Yealie Mansaray; Lauren Marcell; Gillian McKay; Tim O'Dempsey; Victoria Parris; Ruxandra Pinto; Audrey Rangel; Alex P Salam; Jessica Shantha; Vanessa Wolfman; Steven Yeh; Adrienne K Chan; Sharmistha Mishra Journal: Lancet Infect Dis Date: 2015-12-23 Impact factor: 25.071
Authors: Shevin T Jacob; Ian Crozier; William A Fischer; Angela Hewlett; Colleen S Kraft; Marc-Antoine de La Vega; Moses J Soka; Victoria Wahl; Anthony Griffiths; Laura Bollinger; Jens H Kuhn Journal: Nat Rev Dis Primers Date: 2020-02-20 Impact factor: 52.329
Authors: A de St Maurice; E Ervin; R Orone; M Choi; E K Dokubo; P E Rollin; S T Nichol; D Williams; J Brown; R Sacra; J Fankhauser; B Knust Journal: Open Forum Infect Dis Date: 2018-09-21 Impact factor: 3.835