Literature DB >> 26060026

Myocardial injury and protection related to cardiopulmonary bypass.

Stefan De Hert1, Anneliese Moerman2.   

Abstract

During cardiac surgery with cardiopulmonary bypass, the heart is isolated from the circulation. This inevitably induces myocardial ischemia. In addition to this ischemic insult, an additional hit will occur upon reperfusion, which may worsen the extent of tissue damage and organ dysfunction. Over the years, several strategies have been developed that aim to attenuate and/or modulate the extent of this ischemia-reperfusion injury related to the episode of cardiopulmonary bypass. This article reviews the pathophysiology of myocardial injury related to cardiopulmonary bypass and summarizes potential therapeutic strategies that may modulate the extent of this myocardial injury.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  cardioprotection; cardiopulmonary bypass; conditioning; heart; ischemia–reperfusion injury; myocardium

Mesh：

Year:  2015        PMID： 26060026     DOI： 10.1016/j.bpa.2015.03.002

Source DB:  PubMed          Journal:  Best Pract Res Clin Anaesthesiol        ISSN： 1521-6896


  22 in total

1.  Arrhythmias After Stage I Hybrid Palliation in Single-Ventricle Patients.

Authors:  Jeffrey Moore; Diane Paulus; Clifford L Cua; Naomi J Kertesz; Yongjie Miao; John P Cheatham; Mark Galantowicz; Richard Fernandez
Journal:  Pediatr Cardiol       Date:  2016-07-18       Impact factor: 1.655

2.  Cardiopulmonary Bypass-Induced Inflammation and Myocardial Ischemia and Reperfusion Injury Stimulates Accumulation of Soluble MER.

Authors:  Amanda C Becker; Connor W Lantz; Joseph M Forbess; Conrad L Epting; Edward B Thorp
Journal:  Pediatr Crit Care Med       Date:  2021-09-01       Impact factor: 3.971

3.  A pilot study of perioperative esmolol for myocardial protection during on-pump cardiac surgery.

Authors:  Xue Liu; Fengxia Shao; Liu Yang; Youhai Jia
Journal:  Exp Ther Med       Date:  2016-09-20       Impact factor: 2.447

4.  Cardiopulmonary bypass reduces myocardial oxidative stress, inflammation and increases c-kit+CD45- cell population in newborns.

Authors:  Johannes Petersen; Andrey Kazakov; Michael Böhm; Hans-Joachim Schäfers; Ulrich Laufs; Hashim Abdul-Khaliq
Journal:  J Transl Med       Date:  2018-04-27       Impact factor: 5.531

5.  Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats.

Authors:  Dandan Song; Xuelei Liu; Yugang Diao; Yingjie Sun; Guangjie Gao; Tiezheng Zhang; Keyan Chen; Ling Pei
Journal:  Mol Med Rep       Date:  2018-06-20       Impact factor: 2.952

6.  Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery.

Authors:  Chung-Sik Oh; Karam Kim; Woon-Seok Kang; Nam-Sik Woo; Po-Soon Kang; Jun-Seok Kim; Hang-Rae Kim; Seung-Hyun Lee; Seong-Hyop Kim
Journal:  Sci Rep       Date:  2018-07-05       Impact factor: 4.379

7.  Role of Anaesthetic Choice in Improving Outcome after Cardiac Surgery.

Authors:  Mihai Stefan; Daniela Filipescu
Journal:  Rom J Anaesth Intensive Care       Date:  2020-12-31

8.  Severity of hyperoxia as a risk factor in patients undergoing on-pump cardiac surgery.

Authors:  Gabrielius Jakutis; Ieva Norkienė; Donata Ringaitienė; Tomas Jovaiša
Journal:  Acta Med Litu       Date:  2017

9.  Preoperative oral thyroid hormones to prevent euthyroid sick syndrome and attenuate myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass in children: A randomized, double-blind, placebo-controlled trial.

Authors:  Jia-Qiang Zhang; Quan-Yong Yang; Fu-Shan Xue; Wei Zhang; Gui-Zhen Yang; Xu Liao; Fan-Min Meng
Journal:  Medicine (Baltimore)       Date:  2018-09       Impact factor: 1.817

10.  Blood cytokine expression correlates with early multi-organ damage in a mouse model of moderate hypothermia with circulatory arrest using cardiopulmonary bypass.

Authors:  Ruslan Natanov; Faikah Gueler; Christine S Falk; Christian Kühn; Ulrich Maus; Erin C Boyle; Thierry Siemeni; Ann-Katrin Knoefel; Serghei Cebotari; Axel Haverich; Nodir Madrahimov
Journal:  PLoS One       Date:  2018-10-11       Impact factor: 3.240
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