Kung-Ting Kao1,2,3, Nobia Abidi4, Sanjeeva Ranasinha5, Justin Brown4,6, Christine Rodda3,4,7, Zoe McCallum1,3, Margaret Zacharin1,2,3, Peter J Simm1,2,6, Costan G Magnussen8,9, Matthew A Sabin1,2,3,4. 1. Department of Endocrinology and Diabetes, The Royal Children's Hospital, Melbourne, Victoria, Australia. 2. Center for Hormone Research, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia. 3. Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia. 4. Department of Paediatrics, Monash University, Melbourne, Victoria, Australia. 5. School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. 6. Department of Paediatric Endocrinology and Diabetes, Monash Children's Hospital, Melbourne, Victoria, Australia. 7. Western Centre for Health Research, Sunshine Hospital, Melbourne, Victoria, Australia. 8. Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia. 9. Research Centre of Applied and Preventative Cardiovascular Medicine, University of Turku, Turku, Finland.
Abstract
AIM: The aim of this paper was to investigate the relationship between circulating 25-hydroxyvitamin D (25(OH)D) and cardio-metabolic risk factors in a large cohort of obese youth attending tertiary paediatric obesity services. METHODS: We conducted a retrospective cross-sectional study. Data were retrospectively collected from all new consultations of children and adolescents attending obesity outpatient clinics between 2008 and 2011 at the two major paediatric hospitals in Melbourne, Australia. Information collected included demographics, anthropometry, blood pressure, pubertal staging, body composition and fasting serum levels of 25(OH)D, glucose, insulin, cholesterol, triglyceride, high-density lipoprotein, liver function, calcium and phosphate. RESULTS: 25(OH)D data were available in 229 patients (age 3-18 years; 116 men; mean (standard deviation) body mass index ( BMI) Z-score 2.5 (0.5) ). One hundred four (45%) participants were 25(OH)D deficient (<50 nmol/L). Lower serum 25(OH)D levels were associated with higher BMI Z-score (P-trend = 0.001), total fat mass (P-trend = 0.009), systolic (P-trend = 0.03) and diastolic blood pressures(P-trend = 0.009). In multivariable-adjusted regression analysis, 25(OH)D was significantly lower in those with elevated blood pressure after adjustment for BMI(P-trend = 0.004) or total fat mass (P-trend = 0.01). CONCLUSION: Overweight and obese youth attending specialist obesity services have a high prevalence of vitamin D deficiency. In this population, lower levels of vitamin D were seen in those with greater adiposity, and independent of this, in those who had higher blood pressure.
AIM: The aim of this paper was to investigate the relationship between circulating 25-hydroxyvitamin D (25(OH)D) and cardio-metabolic risk factors in a large cohort of obese youth attending tertiary paediatric obesity services. METHODS: We conducted a retrospective cross-sectional study. Data were retrospectively collected from all new consultations of children and adolescents attending obesityoutpatient clinics between 2008 and 2011 at the two major paediatric hospitals in Melbourne, Australia. Information collected included demographics, anthropometry, blood pressure, pubertal staging, body composition and fasting serum levels of 25(OH)D, glucose, insulin, cholesterol, triglyceride, high-density lipoprotein, liver function, calcium and phosphate. RESULTS: 25(OH)D data were available in 229 patients (age 3-18 years; 116 men; mean (standard deviation) body mass index ( BMI) Z-score 2.5 (0.5) ). One hundred four (45%) participants were 25(OH)D deficient (<50 nmol/L). Lower serum 25(OH)D levels were associated with higher BMI Z-score (P-trend = 0.001), total fat mass (P-trend = 0.009), systolic (P-trend = 0.03) and diastolic blood pressures(P-trend = 0.009). In multivariable-adjusted regression analysis, 25(OH)D was significantly lower in those with elevated blood pressure after adjustment for BMI(P-trend = 0.004) or total fat mass (P-trend = 0.01). CONCLUSION: Overweight and obese youth attending specialist obesity services have a high prevalence of vitamin D deficiency. In this population, lower levels of vitamin D were seen in those with greater adiposity, and independent of this, in those who had higher blood pressure.
Authors: Kumaravel Rajakumar; Charity G Moore; Arshad T Khalid; Abbe N Vallejo; Mohamed A Virji; Michael F Holick; Susan L Greenspan; Silva Arslanian; Steven E Reis Journal: Am J Clin Nutr Date: 2020-04-01 Impact factor: 7.045
Authors: Silvia Savastio; Erica Pozzi; Francesco Tagliaferri; Roberta Degrandi; Roberta Cinquatti; Ivana Rabbone; Gianni Bona Journal: Int J Mol Sci Date: 2020-05-16 Impact factor: 5.923
Authors: Mones M Abu Shady; Mai M Youssef; Ebtissam M Salah El-Din; Ola M Abdel Samie; Hala S Megahed; Samar M E Salem; Manal A Mohsen; Ali Abdel Aziz; Safinaz El-Toukhy Journal: ScientificWorldJournal Date: 2016-01-28