S Flamee1, S Gizani2, C Caroni3, L Papagiannoulis1, S Twetman4. 1. Department of Paediatric Dentistry, Dental School, National and Kapodistrian University of Athens, 2 Thivon Str, Goudi, 11527, Athens, Greece. 2. Department of Paediatric Dentistry, Dental School, National and Kapodistrian University of Athens, 2 Thivon Str, Goudi, 11527, Athens, Greece. stgizani@dent.uoa.gr. 3. Department of Mathematics, National Technical University of Athens, 9 Heroon Polytechniou str, 15780, Zografou, Athens, Greece. 4. Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Allé 20, 2200, Copenhagen N, Denmark.
Abstract
AIM: To compare the caries preventive effect of a chlorhexidine/thymol-containing antibacterial varnish with a fluoride varnish when topically applied during the eruption of permanent molars. METHODS: The study group consisted of 189 patients, 5-14 years of age, with one 1st or 2nd permanent molar in the process of eruption. After stratification for type of molar and stage of eruption, the patients were randomised to either quarterly topical applications with an antibacterial varnish (Cervitec(®) Plus; CV group) or biannual applications with a fluoride varnish plus biannual treatments with placebo varnish (Fluor Protector; FV group). The duration of the study was 2 years. The primary endpoint was caries incidence (initial and cavitated) in the erupting molars and the secondary outcome was salivary mutans streptococci (MS) counts. RESULTS: The groups were balanced with respect to socio-economy, oral hygiene, dietary habits and caries experience at baseline. The dropout rate was 11.6 %. The caries incidence was low (< 10 %) in both groups and there was no significant difference between the CV and FV groups with respect to occlusal caries development in the erupting molars (relative risk 1.08, 95 % CI 0.94-1.25). Significantly lower levels of salivary MS were disclosed in the CV group at the end of the study (p < 0.05). CONCLUSIONS: No difference in occlusal caries development in young permanent molars was displayed after topical applications of either a chlorhexidine/thymol varnish or a fluoride varnish during tooth eruption.
RCT Entities:
AIM: To compare the caries preventive effect of a chlorhexidine/thymol-containing antibacterial varnish with a fluoride varnish when topically applied during the eruption of permanent molars. METHODS: The study group consisted of 189 patients, 5-14 years of age, with one 1st or 2nd permanent molar in the process of eruption. After stratification for type of molar and stage of eruption, the patients were randomised to either quarterly topical applications with an antibacterial varnish (Cervitec(®) Plus; CV group) or biannual applications with a fluoride varnish plus biannual treatments with placebo varnish (Fluor Protector; FV group). The duration of the study was 2 years. The primary endpoint was caries incidence (initial and cavitated) in the erupting molars and the secondary outcome was salivary mutans streptococci (MS) counts. RESULTS: The groups were balanced with respect to socio-economy, oral hygiene, dietary habits and caries experience at baseline. The dropout rate was 11.6 %. The caries incidence was low (< 10 %) in both groups and there was no significant difference between the CV and FV groups with respect to occlusal caries development in the erupting molars (relative risk 1.08, 95 % CI 0.94-1.25). Significantly lower levels of salivary MS were disclosed in the CV group at the end of the study (p < 0.05). CONCLUSIONS: No difference in occlusal caries development in young permanent molars was displayed after topical applications of either a chlorhexidine/thymol varnish or a fluoride varnish during tooth eruption.
Authors: Robert J Weyant; Sharon L Tracy; Theresa Tracy Anselmo; Eugenio D Beltrán-Aguilar; Kevin J Donly; William A Frese; Philippe P Hujoel; Timothy Iafolla; William Kohn; Jayanth Kumar; Steven M Levy; Norman Tinanoff; J Timothy Wright; Domenick Zero; Krishna Aravamudhan; Julie Frantsve-Hawley; Daniel M Meyer Journal: J Am Dent Assoc Date: 2013-11 Impact factor: 3.634
Authors: Lídia Audrey Rocha Valadas; Mariana Fernandes Gurgel; Joelma Martins Mororó; Said Gonçalves da Cruz Fonseca; Cristiane Sá Roriz Fonteles; Cibele Barreto Mano de Carvalho; Francisco Vagnaldo Fechine; Edilson Martins Rodrigues Neto; Marta Maria de França Fonteles; Francineudo Oliveira Chagas; Patrícia Leal Dantas Lobo; Mary Anne Medeiros Bandeira Journal: Saudi Pharm J Date: 2018-12-15 Impact factor: 4.330