Literature DB >> 26059354

The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders.

Roy G Cutler1, Simonetta Camandola, Kelli F Malott, Maria A Edelhauser, Mark P Mattson.   

Abstract

High uric acid (UA levels have been correlated with a reduced risk of many neurodegenerative diseases through mechanisms involving chelating Fenton reaction transitional metals, antioxidant quenching of superoxide and hydroxyl free radicals, and as an electron donor that increases antioxidant enzyme activity (e.g. SOD. However, the clinical usefulness of UA is limited by its' low water solubility and propensity to form inflammatory crystals at hyperuricemic levels. This review focuses on the role of UA in neuroprotection, as well as potential strategies aimed at increasing UA levels in the soluble range, and the potential therapeutic use of more water-soluble methyl-UA derivatives from the natural catabolic end-products of dietary caffeine, theophylline, and theobromine.

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Year:  2015        PMID： 26059354      PMCID： PMC5851449          DOI： 10.2174/1568026615666150610143234

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  81 in total

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Journal:  Cell Biochem Biophys       Date:  2000       Impact factor: 2.194

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Authors:  D STETTEN; J Z HEARON
Journal:  Science       Date:  1959-06-26       Impact factor: 47.728

3.  Oral bioavailability of ATP after prolonged administration.

Authors:  Erik J C M Coolen; Ilja C W Arts; Otto Bekers; Chris Vervaet; Aalt Bast; Pieter C Dagnelie
Journal:  Br J Nutr       Date:  2010-12-06       Impact factor: 3.718

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Journal:  J Psychosom Res       Date:  1972-02       Impact factor: 3.006

5.  Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke.

Authors:  Eduardo Romanos; Anna M Planas; Sergio Amaro; Angel Chamorro
Journal:  J Cereb Blood Flow Metab       Date:  2006-04-05       Impact factor: 6.200

6.  Therapeutic value of serum uric acid levels increasing in the treatment of multiple sclerosis.

Authors:  Goran Toncev
Journal:  Vojnosanit Pregl       Date:  2006-10       Impact factor: 0.168

7.  Uric acid levels predict survival in men with amyotrophic lateral sclerosis.

Authors:  Sabrina Paganoni; May Zhang; Alejandro Quiroz Zárate; Matthew Jaffa; Hong Yu; Merit E Cudkowicz; Anne-Marie Wills
Journal:  J Neurol       Date:  2012-02-10       Impact factor: 4.849

8.  Uric acid levels in sera from patients with multiple sclerosis.

Authors:  J Drulović; I Dujmović; N Stojsavljević; S Mesaros; S Andjelković; D Miljković; V Perić; G Dragutinović; J Marinković; Z Lević; M Mostarica Stojković
Journal:  J Neurol       Date:  2001-02       Impact factor: 4.849

9.  Variation in the uric acid transporter gene SLC2A9 and its association with AAO of Parkinson's disease.

Authors:  Maurizio F Facheris; Andrew A Hicks; Cosetta Minelli; Johann M Hagenah; Vladimir Kostic; Susan Campbell; Caroline Hayward; Claudia B Volpato; Cristian Pattaro; Veronique Vitart; Alan Wright; Harry Campbell; Christine Klein; Peter P Pramstaller
Journal:  J Mol Neurosci       Date:  2010-06-30       Impact factor: 3.444

10.  Blood uric acid level and IQ: a study in twin families.

Authors:  E Inouye; K S Park; A Asaka
Journal:  Acta Genet Med Gemellol (Roma)       Date:  1984
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  10 in total

1.  Uric acid enhances longevity and endurance and protects the brain against ischemia.

Authors:  Roy G Cutler; Simonetta Camandola; Neil H Feldman; Jeong Seon Yoon; James B Haran; Sandro Arguelles; Mark P Mattson
Journal:  Neurobiol Aging       Date:  2018-12-12       Impact factor: 4.673

2.  Plasma creatinine and oxidative stress biomarkers in amyotrophic lateral sclerosis.

Authors:  Hiroshi Mitsumoto; Diana C Garofalo; Regina M Santella; Eric J Sorenson; Björn Oskarsson; J Americo M Fernandes; Howard Andrews; Jonathan Hupf; Madison Gilmore; Daragh Heitzman; Richard S Bedlack; Jonathan S Katz; Richard J Barohn; Edward J Kasarskis; Catherine Lomen-Hoerth; Tahseen Mozaffar; Sharon P Nations; Andrea J Swenson; Pam Factor-Litvak
Journal:  Amyotroph Lateral Scler Frontotemporal Degener       Date:  2020-04-10       Impact factor: 4.092

3.  Uric Acid Is Protective After Cerebral Ischemia/Reperfusion in Hyperglycemic Mice.

Authors:  Carles Justicia; Angélica Salas-Perdomo; Isabel Pérez-de-Puig; Lisette H Deddens; Geralda A F van Tilborg; Clara Castellví; Rick M Dijkhuizen; Ángel Chamorro; Anna M Planas
Journal:  Transl Stroke Res       Date:  2016-12-15       Impact factor: 6.829

4.  Association between Serum Uric Acid and Oxidative Stress in Korean Adults.

Authors:  Eun Jeong Ok; Kiyoung Kim; Sat Byul Park
Journal:  Korean J Fam Med       Date:  2018-09-10

5.  Increased Cerebrospinal Fluid Uric Acid Levels in Guillain-Barré Syndrome.

Authors:  Sheng-Hui Chang; Xiao-Bing Tian; Jing Wang; Ming-Qi Liu; Chen-Na Huang; Yuan Qi; Lin-Jie Zhang; Chun-Li Gao; Da-Qi Zhang; Li-Sha Sun; Li Yang
Journal:  Front Neurol       Date:  2020-11-12       Impact factor: 4.003

6.  Association of sleep quality and sleep duration with serum uric acid levels in adults.

Authors:  Yu-Tsung Chou; Chung-Hao Li; Wei-Chen Shen; Yi-Ching Yang; Feng-Hwa Lu; Jin-Shang Wu; Chih-Jen Chang
Journal:  PLoS One       Date:  2020-09-17       Impact factor: 3.240

Review 7.  Hyperuricemia Increases the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis.

Authors:  Zheng Gao; Hekai Shi; Wei Xu; Zhengzhao Guan; Xiuxiu Su; Nuojin Guo; Huijie Ma
Journal:  Int J Endocrinol       Date:  2022-08-21       Impact factor: 2.803

8.  Diuretics: A possible keystone in upholding cognitive health.

Authors:  Tyler DeLoach; Jennifer Beall
Journal:  Ment Health Clin       Date:  2018-03-26

9.  Serum uric acid and left ventricular hypertrophy in hypertensive patients in Ado-Ekiti.

Authors:  Oladapo Adedamola Adewuya; Ebenezer Adekunle Ajayi; Rasaaq Ayodele Adebayo; Opeyemi Ezekiel Ojo; Olatunji Bukola Olaoye
Journal:  Pan Afr Med J       Date:  2020-07-16

10.  Association between Serum Uric Acid Levels and Bone Mineral Density in Postmenopausal Women: A Cross-Sectional and Longitudinal Study.

Authors:  Soyeon Kang; Dongjin Kwon; Jiwoo Lee; Youn-Jee Chung; Mee-Ran Kim; Jeong Namkung; In Cheul Jeung
Journal:  Healthcare (Basel)       Date:  2021-12-04
  10 in total

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