Literature DB >> 26059250

Is fructose malabsorption a cause of irritable bowel syndrome?

James J DiNicolantonio1, Sean C Lucan2.   

Abstract

Irritable Bowel Syndrome (IBS) is a condition that may be marked by abdominal pain, bloating, fullness, indigestion, belching, constipation and/or diarrhea. IBS symptoms can result from malabsorption of fructose. Fructose is a monosaccharide found naturally in small quantities in fruits and some vegetables, and in much larger quantities in industrially manufactured sweets with added sugars (e.g. sucrose and high fructose corn syrup). Fructose malabsorption leads to osmotic diarrhea as well as gas and bloating due to fermentation in the colon. A low-fructose diet has been found to improve IBS symptoms in some patients. This paper discusses the prevalence of fructose malabsorption and considers fructose ingestion as a possible cause of--and fructose restriction as a possible dietary treatment for--IBS.
Copyright © 2015 Elsevier Ltd. All rights reserved.

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Year:  2015        PMID: 26059250      PMCID: PMC4729202          DOI: 10.1016/j.mehy.2015.05.019

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN: 0306-9877            Impact factor:   1.538


  21 in total

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Authors:  Fernando Fernández-Bañares; Mercé Rosinach; Maria Esteve; Montserrat Forné; Jorge C Espinós; Josep Maria Viver
Journal:  Clin Nutr       Date:  2006-01-10       Impact factor: 7.324

Review 2.  Review article: fructose malabsorption and the bigger picture.

Authors:  P R Gibson; E Newnham; J S Barrett; S J Shepherd; J G Muir
Journal:  Aliment Pharmacol Ther       Date:  2007-01-08       Impact factor: 8.171

3.  Fructose malabsorption and symptoms of irritable bowel syndrome: guidelines for effective dietary management.

Authors:  Susan J Shepherd; Peter R Gibson
Journal:  J Am Diet Assoc       Date:  2006-10

Review 4.  Food: the forgotten factor in the irritable bowel syndrome.

Authors:  Shanti Eswaran; Jan Tack; William D Chey
Journal:  Gastroenterol Clin North Am       Date:  2011-03       Impact factor: 3.806

5.  Dietary fructose intolerance: diet modification can impact self-rated health and symptom control.

Authors:  Frederick C Johlin; Mary Panther; Nancy Kraft
Journal:  Nutr Clin Care       Date:  2004 Jul-Sep

6.  A very low-carbohydrate diet improves symptoms and quality of life in diarrhea-predominant irritable bowel syndrome.

Authors:  Gregory L Austin; Christine B Dalton; Yuming Hu; Carolyn B Morris; Jane Hankins; Stephan R Weinland; Eric C Westman; William S Yancy; Douglas A Drossman
Journal:  Clin Gastroenterol Hepatol       Date:  2009-03-10       Impact factor: 11.382

7.  Symptom provocation in irritable bowel syndrome. Effects of differing doses of fructose-sorbitol.

Authors:  P Symons; M P Jones; J E Kellow
Journal:  Scand J Gastroenterol       Date:  1992-11       Impact factor: 2.423

8.  Fructose intolerance in IBS and utility of fructose-restricted diet.

Authors:  Young K Choi; Nancy Kraft; Bridget Zimmerman; Michelle Jackson; Satish S C Rao
Journal:  J Clin Gastroenterol       Date:  2008-03       Impact factor: 3.062

9.  Ability of the normal human small intestine to absorb fructose: evaluation by breath testing.

Authors:  Satish S C Rao; Ashok Attaluri; Leslie Anderson; Phyllis Stumbo
Journal:  Clin Gastroenterol Hepatol       Date:  2007-07-10       Impact factor: 11.382

10.  Sugar malabsorption in functional bowel disease: clinical implications.

Authors:  F Fernández-Bañares; M Esteve-Pardo; R de Leon; P Humbert; E Cabré; J M Llovet; M A Gassull
Journal:  Am J Gastroenterol       Date:  1993-12       Impact factor: 10.864

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  7 in total

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Journal:  Healthcare (Basel)       Date:  2017-04-26

Review 3.  The Role of Carbohydrate Response Element Binding Protein in Intestinal and Hepatic Fructose Metabolism.

Authors:  Katsumi Iizuka
Journal:  Nutrients       Date:  2017-02-22       Impact factor: 5.717

4.  ChREBP-Knockout Mice Show Sucrose Intolerance and Fructose Malabsorption.

Authors:  Takehiro Kato; Katsumi Iizuka; Ken Takao; Yukio Horikawa; Tadahiro Kitamura; Jun Takeda
Journal:  Nutrients       Date:  2018-03-12       Impact factor: 5.717

5.  Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR.

Authors:  Irene Zwarts; Tim van Zutphen; Janine K Kruit; Weilin Liu; Maaike H Oosterveer; Henkjan J Verkade; N Henriette Uhlenhaut; Johan W Jonker
Journal:  Sci Rep       Date:  2019-06-26       Impact factor: 4.379

Review 6.  Biomolecules from Plant Wastes Potentially Relevant in the Management of Irritable Bowel Syndrome and Co-Occurring Symptomatology.

Authors:  Ioana-Miruna Balmus; Dana Copolovici; Lucian Copolovici; Alin Ciobica; Dragos Lucian Gorgan
Journal:  Molecules       Date:  2022-04-08       Impact factor: 4.927

7.  Role of Fructose Malabsorption in Patients With Irritable Bowel Syndrome.

Authors:  Young Kim; Chang Hwan Choi
Journal:  J Neurogastroenterol Motil       Date:  2018-04-30       Impact factor: 4.924

  7 in total

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