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Literature DB >> 26058448

Synthesis and Antiproliferative Activity of Silybin Conjugates with Salinomycin and Monensin.

Michał Antoszczak¹, Greta Klejborowska¹, Monika Kruszyk¹, Ewa Maj², Joanna Wietrzyk², Adam Huczyński¹.

Abstract

Aiming at development of multitarget drugs for the anticancer treatment, new silybin (SIL) conjugates with salinomycin (SAL) and monensin (MON) were synthesized, in mild esterification conditions, and their antiproliferative activity was studied. The conjugates obtained exhibit anticancer activity against HepG2, LoVo and LoVo/DX cancer cell lines. Moreover, MON-SIL conjugate exhibits higher anticancer potential and better selectivity than the corresponding SAL-SIL conjugate.

Entities: Chemical Disease

Keywords: anticancer activity; molecular hybrids; natural products; polyether antibiotics; silibinin

Mesh：

Substances：

Year: 2015 PMID： 26058448 DOI： 10.1111/cbdd.12602

Source DB: PubMed Journal: Chem Biol Drug Des ISSN： 1747-0277 Impact factor: 2.817

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Cited

6 in total

Synthesis and Antiproliferative Activity of Silybin Conjugates with Salinomycin and Monensin.

1. New Hybrids Derived from Podophyllic Aldehyde and Diterpenylhydroquinones with Selectivity toward Osteosarcoma Cells.

2. Synthesis and Anticancer Activity of Dimeric Polyether Ionophores.

3. Synthesis of Lasalocid-Based Bioconjugates and Evaluation of Their Anticancer Activity.

Review 4. Salinomycin as a potent anticancer stem cell agent: State of the art and future directions.

5. Cholesterol-stabilized membrane-active nanopores with anticancer activities.

6. Liver Protection Mechanism and Absorption Promotion Technology of Silybin Based on Intelligent Medical Analysis.