| Literature DB >> 26057872 |
Anne H van Houwelingen, Wendy P J den Elzen, Simon P Mooijaart, Margot Heijmans, Jeanet W Blom, Anton J M de Craen, Jacobijn Gussekloo.
Abstract
Entities:
Year: 2015 PMID: 26057872 PMCID: PMC4461277 DOI: 10.1371/journal.pone.0129985
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Univariate all-cause mortality risks for sex-dependent quartiles of laboratory results included in the laboratory profile (n = 562)
| Quartile of laboratory results | p for trend | P for 4th quartile compared to the other 3 quartilescombined | ||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |||
| C-reactive protein | 1 (ref) | 1.10 (0.75–1.61) | 1.36 (0.96–1.94) | 2.11 (1.51–2.95 | <0.001 | <0.001 |
| Homocysteine | 1 (ref) | 1.14 (0.76–1.71) | 2.04 (1.40–2.60) | 2.75 (1.92–3.96) | <0.001 | <0.001 |
| Hemoglobin | 1 (ref) | 0.98 (0.67–1.42) | 1.04 (0.72–1.48) | 1.82 (1.31–2.54) | <0.001 | <0.001 |
| High density lipoprotein cholesterol | 1 (ref) | 1.04 (0.72–1.50) | 1.01 (0.70–1.47) | 1.86 (1.33–2.60) | <0.001 | <0.001 |
| Alanine transaminase | 1 (ref) | 1.00 (0.69–1.44) | 0.88 (0.61–1.26) | 1.72 (1.23–2.39) | 0.005 | 0.004 |
| Albumin | 1 (ref) | 1.41 (0.94–2.19) | 2.10 (1.45–3.06) | 3.39 (2.33–4.95) | <0.001 | <0.001 |
| Creatinin clearance | 1 (ref) | 0.96 (0.66–1.41) | 1.32 (0.92–1.89) | 1.85 (1.31–2.61) | <0.001 | <0.001 |
Data represent hazard ratios and 95% confidence intervals, calculated with the univariate Cox-proportional hazard model
Laboratory results are divided into sex-dependent quartiles
25th, 50th and 75th percentile limits of laboratory results stratified for sex:
Hemoglobin: male 12.5–13.4–14.2 g/dL; female 12.0–12.8–13.6 g/dL
Hemoglobin: male 12.5–13.4–14.2 g/dL; female 12.0–12.8–13.6 g/dL
Alanine transaminase: male 11-15-20 U/L; female: 11-14-17 U/L
Albumin: male: 4.0–4.2–4.4 g/dL; female: 4.0–4.2–4.4 g/dL
Creatinin clearance: male: 39.4–47.2–53.9 ml/min; female: 36.8–43.4–50.8 ml/min
C-reactive protein: male: 2-4-8 mg/L; female: 1-4-8 mg/L
Homocysteine: male: 10.9–13.5–17.4 umol/L, female: 10.2–12.2–15.4 umol/L
* highest to lowest quartile