Literature DB >> 26057817

Retraction: Mode of binding of the antithyroid drug propylthiouracil to mammalian haem peroxidases.

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Abstract

The results in the article by Singh et al. [(2015), Acta Cryst. F71, 304-310] have been brought into question and the article is retracted.

Entities:  

Keywords:  antithyroid drug; distal haem side; lactoperoxidase; propylthiouracil; retraction

Year:  2015        PMID: 26057817      PMCID: PMC4461352          DOI: 10.1107/S2053230X15006962

Source DB:  PubMed          Journal:  Acta Crystallogr F Struct Biol Commun        ISSN: 2053-230X            Impact factor:   1.056


Concerns have been raised about the results and modelling of the ligand in the distal heme-pockets of the structure reported in the article by Singh et al. (2015 ▶). Following further investigation, the authors and Editors have agreed to retract the publication. The original PDB entry 4qyq has been obsoleted. The Editors thank the communicating author for his positive engagement, and for addressing issues raised in a timely fashion, and apologise to readers for any inconvenience.
  1 in total

1.  Mode of binding of the antithyroid drug propylthiouracil to mammalian haem peroxidases.

Authors:  R P Singh; A Singh; G S Kushwaha; A K Singh; P Kaur; S Sharma; T P Singh
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2015-02-19       Impact factor: 1.056

  1 in total
  1 in total

1.  Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives as Potential Antithyroid Agents.

Authors:  Samir M Awad; Yasser M Zohny; Sahar A Ali; Shahenda Mahgoub; Ahmed M Said
Journal:  Molecules       Date:  2018-11-08       Impact factor: 4.411

  1 in total

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