Uğur Çakır1, Taha Can Tuman, Osman Yıldırım. 1. Department of Psychiatry, Abant Izzet Baysal University School of Medicine, 14280, Golkoy Kampus, Bolu, Turkey, ugur_cakir@yahoo.com.
Abstract
BACKGROUND: In this study, it has been aimed to investigate whether neutrophil-lymphocyte ratio (NLR) was higher in non-obese patients with bipolar disorder (BD) than in a healthy control group matched for age, sex, and body mass index, and also to determine if there was an interaction between NLR and severity of the bipolar disorder. SUBJECTS AND METHODS: In this retrospective study, 103 non-obese patients with BD and 126 healthy control subjects were analyzed for complete blood count. The Young Mania Rating Scale (YMRS) was used to determine the severity of the disorder. RESULTS: The NLR was higher in female patients than in female comparison subjects (3.2±2.2; versus 1.7±0.4) (p<0.001). Also, compared with the healthy male subjects, the male patients had significantly higher neutrophil/lymphocyte ratio (3.3±2.4; versus 2.0±0.7) (p<0.001). In the patients with bipolar disorder, NLR did not significantly correlate with severity (as measured with the YMRS) (r=0.052; p=0.204) and duration of the disorder (r=0.045; p=0.301). CONCLUSIONS: Results of this study revealed that patients with bipolar disorder have statistically significant elevated NRL than healthy compares. According to this finding, elevated levels of NLR may be involved in inflammatory pathophysiology of bipolar disorder. Further studies are needed for a better understanding of the mechanism between elevation of NRL in patients with bipolar disorder.
BACKGROUND: In this study, it has been aimed to investigate whether neutrophil-lymphocyte ratio (NLR) was higher in non-obesepatients with bipolar disorder (BD) than in a healthy control group matched for age, sex, and body mass index, and also to determine if there was an interaction between NLR and severity of the bipolar disorder. SUBJECTS AND METHODS: In this retrospective study, 103 non-obesepatients with BD and 126 healthy control subjects were analyzed for complete blood count. The Young Mania Rating Scale (YMRS) was used to determine the severity of the disorder. RESULTS: The NLR was higher in female patients than in female comparison subjects (3.2±2.2; versus 1.7±0.4) (p<0.001). Also, compared with the healthy male subjects, the male patients had significantly higher neutrophil/lymphocyte ratio (3.3±2.4; versus 2.0±0.7) (p<0.001). In the patients with bipolar disorder, NLR did not significantly correlate with severity (as measured with the YMRS) (r=0.052; p=0.204) and duration of the disorder (r=0.045; p=0.301). CONCLUSIONS: Results of this study revealed that patients with bipolar disorder have statistically significant elevated NRL than healthy compares. According to this finding, elevated levels of NLR may be involved in inflammatory pathophysiology of bipolar disorder. Further studies are needed for a better understanding of the mechanism between elevation of NRL in patients with bipolar disorder.
Authors: Laura Fusar-Poli; Antimo Natale; Andrea Amerio; Patriciu Cimpoesu; Pietro Grimaldi Filioli; Eugenio Aguglia; Mario Amore; Gianluca Serafini; Andrea Aguglia Journal: Brain Sci Date: 2021-01-06
Authors: Ángela Velasco; Julia Rodríguez-Revuelta; Emilie Olié; Iciar Abad; Abel Fernández-Peláez; Aurélie Cazals; Sébastien Guillaume; Lorena de la Fuente-Tomás; Luis Jiménez-Treviño; Laura Gutiérrez; Paz García-Portilla; Julio Bobes; Philippe Courtet; Pilar A Sáiz Journal: Eur Psychiatry Date: 2020-02-17 Impact factor: 5.361