Literature DB >> 26057222

Ferrocene-pyrimidine conjugates: Synthesis, electrochemistry, physicochemical properties and antiplasmodial activities.

Rakesh Chopra1, Carmen de Kock2, Peter Smith2, Kelly Chibale3, Kamaljit Singh4.   

Abstract

The promise of hybrid antimalarial agents and the precedence set by the antimalarial drug ferroquine prompted us to design ferrocene-pyrimidine conjugates. Herein, we report the synthesis, electrochemistry and anti-plasmodial evaluation of ferrocenyl-pyrimidine conjugates against chloroquine susceptible NF54 strain of the malaria parasite Plasmodium falciparum. Also their physicochemical properties have been studied.
Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Antiplasmodial studies; Ferrocene conjugates; Ferrocene/ferrocenium redox couple; Huisgen 1,3-dipolar cycloaddition; Lipophilicity

Mesh：

Substances：

Year:  2015        PMID： 26057222     DOI： 10.1016/j.ejmech.2015.05.043

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  5 in total

1.  Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.

Authors:  Elumalai Pavadai; Farah El Mazouni; Sergio Wittlin; Carmen de Kock; Margaret A Phillips; Kelly Chibale
Journal:  J Chem Inf Model       Date:  2016-03-08       Impact factor: 4.956

Review 2.  Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?

Authors:  Drishti Agarwal; Rinkoo D Gupta; Satish K Awasthi
Journal:  Antimicrob Agents Chemother       Date:  2017-04-24       Impact factor: 5.191

Review 3.  Ferrocene-Based Compounds with Antimalaria/Anticancer Activity.

Authors:  Sijongesonke Peter; Blessing Atim Aderibigbe
Journal:  Molecules       Date:  2019-10-07       Impact factor: 4.411

Review 4.  Combination Therapy Strategies for the Treatment of Malaria.

Authors:  Sibusiso Alven; Blessing Aderibigbe
Journal:  Molecules       Date:  2019-10-07       Impact factor: 4.411

5.  2-Amino-4-ferrocenyl-thia-zole.

Authors:  Bertin Anzaldo; Pankaj Sharma; Claudia P Villamizar; Rene Gutierrez Perez; Rubén A Toscano
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2022-07-19
  5 in total

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