Lian-Xing Zhao1, Bo Liu1, Chun-Sheng Li1. 1. Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Abstract
BACKGROUND: Venous thromboembolism (VTE), including both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common, lethal disorder that affects hospitalized and non-hospitalized patients. This study aimed to review the progress in the research into VTE. DATA SOURCES: We reviewed the studies about VTE and verified different genetic polymoriphisms of VTE. RESULTS: The pathogenesis of VTE involves hereditary and acquired factors. Many studies indicated that the disorder of coagulation and fibirnolytic system is of utmost importance to this disease. Genetic polymoriphism-related VTE demonstrated significant differences among geographies and ethnicities. CONCLUSION: VTE has many risk factors, but genetic factors play an important role.
BACKGROUND:Venous thromboembolism (VTE), including both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common, lethal disorder that affects hospitalized and non-hospitalized patients. This study aimed to review the progress in the research into VTE. DATA SOURCES: We reviewed the studies about VTE and verified different genetic polymoriphisms of VTE. RESULTS: The pathogenesis of VTE involves hereditary and acquired factors. Many studies indicated that the disorder of coagulation and fibirnolytic system is of utmost importance to this disease. Genetic polymoriphism-related VTE demonstrated significant differences among geographies and ethnicities. CONCLUSION:VTE has many risk factors, but genetic factors play an important role.
Authors: Sven Danckwardt; Niels H Gehring; Gabriele Neu-Yilik; Patrick Hundsdoerfer; Margit Pforsich; Ute Frede; Matthias W Hentze; Andreas E Kulozik Journal: Blood Date: 2004-04-01 Impact factor: 22.113
Authors: J M Brugge; P Simioni; F Bernardi; D Tormene; B Lunghi; G Tans; A Pagnan; J Rosing; E Castoldi Journal: J Thromb Haemost Date: 2005-12 Impact factor: 5.824
Authors: D A Lane; R J Olds; M Boisclair; V Chowdhury; S L Thein; D N Cooper; M Blajchman; D Perry; J Emmerich; M Aiach Journal: Thromb Haemost Date: 1993-08-02 Impact factor: 5.249
Authors: J A He; X H Hu; Y Y Fan; J Yang; Z S Zhang; C W Liu; D H Yang; J Zhang; S J Xin; Q Zhang; Z Q Duan Journal: Eur J Vasc Endovasc Surg Date: 2009-10-20 Impact factor: 7.069