| Literature DB >> 26055641 |
Malin Bern1, Kine Marita Knudsen Sand1, Jeannette Nilsen2, Inger Sandlie1, Jan Terje Andersen3.
Abstract
Albumin is the most abundant protein in blood and acts as a molecular taxi for a plethora of small insoluble substances such as nutrients, hormones, metals and toxins. In addition, it binds a range of medical drugs. It has an unusually long serum half-life of almost 3weeks, and although the structure and function of albumin has been studied for decades, a biological explanation for the long half-life has been lacking. Now, recent research has unravelled that albumin-binding cellular receptors play key roles in the homeostatic regulation of albumin. Here, we review our current understanding of albumin homeostasis with a particular focus on the impact of the cellular receptors, namely the neonatal Fc receptor (FcRn) and the cubilin-megalin complex, and we discuss their importance on uses of albumin in drug delivery.Entities:
Keywords: Albumin; Cubilin; Engineering; FcRn; Half-life; Megalin; Therapeutics
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Year: 2015 PMID： 26055641 DOI： 10.1016/j.jconrel.2015.06.006
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776