Literature DB >> 26055530

Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds.

Thais Gaban Passalacqua1, Luiz Antonio Dutra2, Letícia de Almeida1, Angela Maria Arenas Velásquez1, Fabio Aurelio Esteves Torres1, Paulo Renato Yamasaki3, Mariana Bastos dos Santos4, Luis Octavio Regasini4, Paul A M Michels5, Vanderlan da Silva Bolzani6, Marcia A S Graminha7.   

Abstract

Chalcones form a class of compounds that belong to the flavonoid family and are widely distributed in plants. Their simple structure and the ease of preparation make chalcones attractive scaffolds for the synthesis of a large number of derivatives enabling the evaluation of the effects of different functional groups on biological activities. In this Letter, we report the successful synthesis of a series of novel prenylated chalcones via Claisen-Schmidt condensation and the evaluation of their effect on the viability of the Trypanosomatidae parasites Leishmania amazonensis, Leishmania infantum and Trypanosoma cruzi.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Drug discovery; Leishmania amazonensis; Leishmania infantum; Leishmanicidal activity; Prenylated chalcone; Trypanocidal activity; Trypanosoma cruzi

Mesh：

Substances：

Year:  2015        PMID： 26055530     DOI： 10.1016/j.bmcl.2015.05.072

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Short-term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils.

Authors:  Mônica S Campos; João P A Silva; Danilo S Lima; Luis O Regasini; Mara Rúbia Marques; Manoel F Biancardi; Sebastião R Taboga; Fernanda C A Santos
Journal:  Int J Exp Pathol       Date:  2019-05-26       Impact factor: 1.925

2.  1,5-Benzothiazepine Derivatives: Green Synthesis, In Silico and In Vitro Evaluation as Anticancer Agents.

Authors:  Michelyne Haroun; Santosh S Chobe; Rajasekhar Reddy Alavala; Savita M Mathure; Risy Namratha Jamullamudi; Charushila K Nerkar; Vijay Kumar Gugulothu; Christophe Tratrat; Mohammed Monirul Islam; Katharigatta N Venugopala; Mohammed Habeebuddin; Mallikarjun Telsang; Nagaraja Sreeharsha; Md Khalid Anwer
Journal:  Molecules       Date:  2022-06-10       Impact factor: 4.927

3.  New Insights into the Mechanism of Action of the Cyclopalladated Complex (CP2) in Leishmania: Calcium Dysregulation, Mitochondrial Dysfunction, and Cell Death.

Authors:  Angela M A Velásquez; Paula J Bartlett; Irwin A P Linares; Thais G Passalacqua; Daphne D L Teodoro; Kely B Imamura; Stela Virgilio; Luiz R O Tosi; Aline de Lima Leite; Marilia A R Buzalaf; Jecika M Velasques; Adelino V G Netto; Andrew P Thomas; Marcia A S Graminha
Journal:  Antimicrob Agents Chemother       Date:  2021-10-11       Impact factor: 5.938

4.  Sensitive fluorescent chemosensor for Hg(II) in aqueous solution using 4'-dimethylaminochalcone.

Authors:  Marco Mellado; Nicole Roldán; Rodrigo Miranda; Luis F Aguilar; Manuel A Bravo; Waldo Quiroz
Journal:  J Fluoresc       Date:  2022-04-20       Impact factor: 2.525

5.  Efficacy of a Binuclear Cyclopalladated Compound Therapy for Cutaneous Leishmaniasis in the Murine Model of Infection with Leishmania amazonensis and Its Inhibitory Effect on Topoisomerase 1B.

Authors:  Angela Maria Arenas Velásquez; Willian Campos Ribeiro; Vutey Venn; Silvia Castelli; Mariana Santoro de Camargo; Renata Pires de Assis; Rodrigo Alves de Souza; Aline Rimoldi Ribeiro; Thaís Gaban Passalacqua; João Aristeu da Rosa; Amanda Martins Baviera; Antonio Eduardo Mauro; Alessandro Desideri; Elmo Eduardo Almeida-Amaral; Marcia A S Graminha
Journal:  Antimicrob Agents Chemother       Date:  2017-07-25       Impact factor: 5.191

6.  Licochalcone a Exhibits Leishmanicidal Activity in vitro and in Experimental Model of Leishmania (Leishmania) Infantum.

Authors:  Julia M Souza; Érica A A de Carvalho; Ana Carolina B B Candido; Rafael P de Mendonça; Maria Fernanda da Silva; Renato L T Parreira; Fernanda G G Dias; Sérgio R Ambrósio; Andrea T Arantes; Ademar A da Silva Filho; Aline N Nascimento; Monique R Costa; Mirela I Sairre; Rodrigo C S Veneziani; Lizandra G Magalhães
Journal:  Front Vet Sci       Date:  2020-12-10

7.  Synthesis and Evaluation of Trypanocidal Activity of Chromane-Type Compounds and Acetophenones.

Authors:  Luis A González; Sara Robledo; Yulieth Upegui; Gustavo Escobar; Wiston Quiñones
Journal:  Molecules       Date:  2021-11-23       Impact factor: 4.411

8.  Antimicrobial activity of RP-1 peptide conjugate with ferrocene group.

Authors:  Natalia C S Costa; Julia P Piccoli; Norival A Santos-Filho; Leandro C Clementino; Ana M Fusco-Almeida; Sarah R De Annunzio; Carla R Fontana; Juliane B M Verga; Silas F Eto; João M Pizauro-Junior; Marcia A S Graminha; Eduardo M Cilli
Journal:  PLoS One       Date:  2020-03-26       Impact factor: 3.240

9.  Synthesis, In Silico and In Vitro Evaluation for Acetylcholinesterase and BACE-1 Inhibitory Activity of Some N-Substituted-4-Phenothiazine-Chalcones.

Authors:  Thai-Son Tran; Minh-Tri Le; Thi-Cam-Vi Nguyen; The-Huan Tran; Thanh-Dao Tran; Khac-Minh Thai
Journal:  Molecules       Date:  2020-08-27       Impact factor: 4.411

10.  Anti-trypanosomal screening of Salvadoran flora.

Authors:  Ulises G Castillo; Ayato Komatsu; Morena L Martínez; Jenny Menjívar; Marvin J Núñez; Yoshinori Uekusa; Yuji Narukawa; Fumiyuki Kiuchi; Junko Nakajima-Shimada
Journal:  J Nat Med       Date:  2021-09-16       Impact factor: 2.343
  10 in total

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