Literature DB >> 26055380

Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand.

Tiphaine Gaillard1, Kanlaya Sriprawat2, Sébastien Briolant3, Chirapat Wangsing2, Nathalie Wurtz4, Meïli Baragatti5, Morgane Lavina4, Aurélie Pascual6, François Nosten7, Bruno Pradines8.   

Abstract

Determinations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC50s of 13.15 μM and 31.60 μM). There was no significant difference between the group with low IC50s versus the group with high IC50s with regard to copy numbers of the Plasmodium falciparum tetQ (pftetQ) gene (P = 0.11) or pfmdt gene (P = 0.87) or the number of PfTetQ KYNNNN repeats (P = 0.72).
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26055380      PMCID： PMC4505297          DOI： 10.1128/AAC.00345-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Absence of association between ex vivo susceptibility to doxycycline and pftetQ and pfmdt copy numbers in Plasmodium falciparum isolates from Dakar, Senegal.

Authors:  T Gaillard; B Fall; A Tall; N Wurtz; B Diatta; M Lavina; K B Fall; F D Sarr; E Baret; Y Diémé; B Wade; R Bercion; S Briolant; B Pradines
Journal:  Clin Microbiol Infect       Date:  2012-04-25       Impact factor: 8.067

2.  Urban malaria in Dakar, Senegal: chemosusceptibility and genetic diversity of Plasmodium falciparum isolates.

Authors:  Maud Henry; Ibrahima Diallo; Julien Bordes; Sidy Ka; Bruno Pradines; Bakary Diatta; Papa Sialou M'Baye; Mouhamadou Sane; Massamba Thiam; Pape Mandoumbe Gueye; Boubacar Wade; Jean Etienne Touze; Jean-Marc Debonne; Christophe Rogier; Thierry Fusai
Journal:  Am J Trop Med Hyg       Date:  2006-07       Impact factor: 2.345

3.  In vitro and in vivo antimalarial efficacies of optimized tetracyclines.

Authors:  Michael P Draper; Beena Bhatia; Haregewein Assefa; Laura Honeyman; Lynne K Garrity-Ryan; Atul K Verma; Jiri Gut; Kelley Larson; Janice Donatelli; Ann Macone; Kevin Klausner; Raina G Leahy; Aleksandrs Odinecs; Kwasi Ohemeng; Philip J Rosenthal; Mark L Nelson
Journal:  Antimicrob Agents Chemother       Date:  2013-04-29       Impact factor: 5.191

4.  Reliability of antimalarial sensitivity tests depends on drug mechanisms of action.

Authors:  Sharon Wein; Marjorie Maynadier; Christophe Tran Van Ba; Rachel Cerdan; Suzanne Peyrottes; Laurent Fraisse; Henri Vial
Journal:  J Clin Microbiol       Date:  2010-03-10       Impact factor: 5.948

5.  Multinormal in vitro distribution model suitable for the distribution of Plasmodium falciparum chemosusceptibility to doxycycline.

Authors:  Sébastien Briolant; Meili Baragatti; Philippe Parola; Fabrice Simon; Adama Tall; Cheikh Sokhna; Philippe Hovette; Modeste Mabika Mamfoumbi; Jean-Louis Koeck; Jean Delmont; André Spiegel; Jacky Castello; Jean Pierre Gardair; Jean Francois Trape; Maryvonne Kombila; Philippe Minodier; Thierry Fusai; Christophe Rogier; Bruno Pradines
Journal:  Antimicrob Agents Chemother       Date:  2008-12-01       Impact factor: 5.191

6.  Susceptibility of Plasmodium falciparum isolates to doxycycline is associated with pftetQ sequence polymorphisms and pftetQ and pfmdt copy numbers.

Authors:  Sébastien Briolant; Nathalie Wurtz; Agnès Zettor; Christophe Rogier; Bruno Pradines
Journal:  J Infect Dis       Date:  2010-01-01       Impact factor: 5.226

7.  Oxygen- and time-dependent effects of antibiotics and selected mitochondrial inhibitors on Plasmodium falciparum in culture.

Authors:  A A Divo; T G Geary; J B Jensen
Journal:  Antimicrob Agents Chemother       Date:  1985-01       Impact factor: 5.191

8.  Use of the atmospheric generators for capnophilic bacteria Genbag-CO2 for the evaluation of in vitro Plasmodium falciparum susceptibility to standard anti-malarial drugs.

Authors:  Aurélie Pascual; Leonardo K Basco; Eric Baret; Rémy Amalvict; Dominique Travers; Christophe Rogier; Bruno Pradines
Journal:  Malar J       Date:  2011-01-14       Impact factor: 2.979

9.  Ex vivo susceptibility of Plasmodium falciparum isolates from Dakar, Senegal, to seven standard anti-malarial drugs.

Authors:  Bécaye Fall; Silmane Diawara; Kowry Sow; Eric Baret; Bakary Diatta; Khadidiatou B Fall; Pape S Mbaye; Fatou Fall; Yaya Diémé; Christophe Rogier; Boubacar Wade; Raymond Bercion; Bruno Pradines
Journal:  Malar J       Date:  2011-10-20       Impact factor: 2.979

10.  PftetQ and pfmdt copy numbers as predictive molecular markers of decreased ex vivo doxycycline susceptibility in imported Plasmodium falciparum malaria.

Authors:  Tiphaine Gaillard; Sébastien Briolant; Sandrine Houzé; Meïli Baragatti; Nathalie Wurtz; Véronique Hubert; Morgane Lavina; Aurélie Pascual; Christelle Travaillé; Jacques Le Bras; Bruno Pradines
Journal:  Malar J       Date:  2013-11-14       Impact factor: 2.979
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  3 in total

1.  Absence of association between Plasmodium falciparum small sub-unit ribosomal RNA gene mutations and in vitro decreased susceptibility to doxycycline.

Authors:  Tiphaine Gaillard; Nathalie Wurtz; Sandrine Houzé; Kanlaya Sriprawat; Chirapat Wangsing; Véronique Hubert; Jacques Lebras; François Nosten; Sébastien Briolant; Bruno Pradines
Journal:  Malar J       Date:  2015-09-17       Impact factor: 2.979

2.  Malaria, tuberculosis and HIV: what's new? Contribution of the Institut Hospitalo-Universitaire Méditerranée Infection in updated data.

Authors:  Lionel Almeras; Leonardo K Basco; Cheikh Sokhna; Stéphane Ranque; Philippe Parola; Christian Devaux; Philippe Brouqui; Michel Drancourt; Bruno Pradines
Journal:  New Microbes New Infect       Date:  2018-07-04

Review 3.  Tetracyclines in malaria.

Authors:  Tiphaine Gaillard; Marylin Madamet; Bruno Pradines
Journal:  Malar J       Date:  2015-11-10       Impact factor: 2.979
  3 in total

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