Literature DB >> 26055367

Effect of Qnr on Plasmid Gyrase Toxins CcdB and ParE.

Yee Gyung Kwak1, George A Jacoby2, David C Hooper3.   

Abstract

Plasmid toxins CcdB and ParE are part of addiction systems promoting plasmid maintenance. Both target host DNA gyrase, as do quinolones and plasmid-determined Qnr proteins that protect gyrase from quinolone inhibition. We cloned qnrB4, qnrS1, ccdB, parE, and the antitoxin-encoding genes ccdA and parD on compatible plasmids and tested them in combination. CcdB and ParE had no specific effect on quinolone susceptibility or Qnr protection, and Qnr did not act as a CcdB or ParE antitoxin.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26055367      PMCID： PMC4505230          DOI： 10.1128/AAC.00524-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Mutagenesis-based definitions and probes of residue burial in proteins.

Authors:  Kanika Bajaj; Purbani Chakrabarti; Raghavan Varadarajan
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-26       Impact factor: 11.205

2.  qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States.

Authors:  A Robicsek; J Strahilevitz; D F Sahm; G A Jacoby; D C Hooper
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

3.  Plasmid-mediated quinolone resistance in non-Typhi serotypes of Salmonella enterica.

Authors:  Kathryn Gay; Ari Robicsek; Jacob Strahilevitz; Chi Hye Park; George Jacoby; Timothy J Barrett; Felicita Medalla; Tom M Chiller; David C Hooper
Journal:  Clin Infect Dis       Date:  2006-06-20       Impact factor: 9.079

4.  Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter.

Authors:  L M Guzman; D Belin; M J Carson; J Beckwith
Journal:  J Bacteriol       Date:  1995-07       Impact factor: 3.490

5.  ParE toxin encoded by the broad-host-range plasmid RK2 is an inhibitor of Escherichia coli gyrase.

Authors:  Yong Jiang; Joe Pogliano; Donald R Helinski; Igor Konieczny
Journal:  Mol Microbiol       Date:  2002-05       Impact factor: 3.501

6.  Mechanism of plasmid-mediated quinolone resistance.

Authors:  John H Tran; George A Jacoby
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-09       Impact factor: 11.205

7.  Fluoroquinolone resistance and plasmid addiction systems: self-imposed selection pressure?

Authors:  Matthew J Ellington; Neil Woodford
Journal:  J Antimicrob Chemother       Date:  2006-04-03       Impact factor: 5.790

8.  Properties of an R factor from Pseudomonas aeruginosa.

Authors:  N Datta; R W Hedges; E J Shaw; R B Sykes; M H Richmond
Journal:  J Bacteriol       Date:  1971-12       Impact factor: 3.490

9.  Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes.

Authors:  P Bernard; M Couturier
Journal:  J Mol Biol       Date:  1992-08-05       Impact factor: 5.469

10.  Prevalence of plasmid-mediated quinolone resistance determinants over a 9-year period.

Authors:  Hong Bin Kim; Chi Hye Park; Chung Jong Kim; Eui-Chong Kim; George A Jacoby; David C Hooper
Journal:  Antimicrob Agents Chemother       Date:  2008-12-08       Impact factor: 5.191
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  3 in total

Review 1.  Transferable Mechanisms of Quinolone Resistance from 1998 Onward.

Authors:  Joaquim Ruiz
Journal:  Clin Microbiol Rev       Date:  2019-08-14       Impact factor: 26.132

2.  Protective effect of Qnr on agents other than quinolones that target DNA gyrase.

Authors:  George A Jacoby; Marian A Corcoran; David C Hooper
Journal:  Antimicrob Agents Chemother       Date:  2015-08-03       Impact factor: 5.191

3.  The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics.

Authors:  Meenakumari Muthuramalingam; John C White; Tamiko Murphy; Jessica R Ames; Christina R Bourne
Journal:  Mol Microbiol       Date:  2018-12-05       Impact factor: 3.501
  3 in total

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