| Literature DB >> 2605526 |
A I Spielman1, I Mody, J G Brand, G Whitney, J F MacDonald, M W Salter.
Abstract
Individual taste receptor cells were isolated from the tongue of the mouse by enzymatic treatment followed by mechanical dissociation. The cells were morphologically identical with taste cells from amphibians. Whole-cell voltage-clamp recordings indicated that the murine taste cells possess a variety of voltage-dependent inward and outward currents. Delayed rectifier currents were blocked by denatonium benzoate, one of the most bitter compounds known. This preparation should permit a detailed electrophysiologcal investigation of taste transduction in mammals at the level of taste receptor cells.Entities:
Mesh：
Year: 1989 PMID： 2605526 DOI： 10.1016/0006-8993(89)91684-3
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252