Magali Saint Martin1,2, Frédéric Roche1,2, Thierry Thomas3, Philippe Collet3, Jean Claude Barthélémy1,2, Emilia Sforza1,2. 1. Service De Physiologie Clinique Et De L'exercice, CHU Nord, Saint-Etienne, Faculté De Médecine Jacques Lisfranc, Université Jean Monnet, Saint-Etienne, France. 2. Communautés d'universités et établissements (COMUE), PRES Université De Lyon, France. 3. Service De Rhumatologie, CHU Saint-Etienne, Faculté De Médecine Jacques Lisfranc, Université Jean Monnet, Saint-Etienne, France.
Abstract
OBJECTIVE: Obesity and aging are considered risk factors for developing sleep apnea syndrome (OSA). The aim of this study was to determine the association between body fat composition and OSA in healthy elderly subjects examined in a 7-year longitudinal study. METHODS: A total of 209 elderly with unrecognized OSA aged 68.3 ± 0.8 years underwent a clinical, ambulatory nocturnal respiratory recording, and anthropometric as well as body fat composition assessment by dual-energy X-ray absorptiometry (DEXA) at baseline and follow-up. RESULTS: At study entry, 50.3% of the population showed an apnea+hypopnea index (AHI) <15 with a mean AHI of 16.8 ± 11. At follow-up, a reduction of OSA cases (42%) was evident with a mean AHI of 14.6 ± 10.2. The DEXA data demonstrated that body mass and total lean mass were reduced at follow-up, while central and peripheral fat mass showed a slight increase. Correlation analysis between the changes in DEXA measurements versus the changes in AHI and the indices of nocturnal hypoxemia showed an absence of a statistical correlation. CONCLUSIONS: The lack of correlation between the DEXA measurement changes and the changes in the AHI confirm our previous data on the absence of a central fat mass effect on OSA in the elderly.
OBJECTIVE: Obesity and aging are considered risk factors for developing sleep apnea syndrome (OSA). The aim of this study was to determine the association between body fat composition and OSA in healthy elderly subjects examined in a 7-year longitudinal study. METHODS: A total of 209 elderly with unrecognized OSA aged 68.3 ± 0.8 years underwent a clinical, ambulatory nocturnal respiratory recording, and anthropometric as well as body fat composition assessment by dual-energy X-ray absorptiometry (DEXA) at baseline and follow-up. RESULTS: At study entry, 50.3% of the population showed an apnea+hypopnea index (AHI) <15 with a mean AHI of 16.8 ± 11. At follow-up, a reduction of OSA cases (42%) was evident with a mean AHI of 14.6 ± 10.2. The DEXA data demonstrated that body mass and total lean mass were reduced at follow-up, while central and peripheral fat mass showed a slight increase. Correlation analysis between the changes in DEXA measurements versus the changes in AHI and the indices of nocturnal hypoxemia showed an absence of a statistical correlation. CONCLUSIONS: The lack of correlation between the DEXA measurement changes and the changes in the AHI confirm our previous data on the absence of a central fat mass effect on OSA in the elderly.
Authors: David Stevens; Sarah Appleton; Andrew D Vincent; Yohannes Melaku; Sean Martin; Tiffany Gill; Catherine Hill; Andrew Vakulin; Robert Adams; Gary Wittert Journal: Nat Sci Sleep Date: 2020-11-10
Authors: Tarek Bekfani; Christoph Schöbel; Charlotte Pietrock; Miroslava Valentova; Nicole Ebner; Wolfram Döhner; P Christian Schulze; Stefan D Anker; Stephan von Haehling Journal: ESC Heart Fail Date: 2020-06-23
Authors: Anna Brzecka; Jerzy Leszek; Ghulam Md Ashraf; Maria Ejma; Marco F Ávila-Rodriguez; Nagendra S Yarla; Vadim V Tarasov; Vladimir N Chubarev; Anna N Samsonova; George E Barreto; Gjumrakch Aliev Journal: Front Neurosci Date: 2018-05-31 Impact factor: 4.677