Axel Patrice Villani1, Marie Rouzaud2, Morgane Sevrain3, Thomas Barnetche4, Carle Paul5, Marie-Aleth Richard6, Marie Beylot-Barry2, Laurent Misery3, Pascal Joly7, Michel Le Maitre8, Selim Aractingi9, François Aubin10, Alain Cantagrel11, Jean-Paul Ortonne12, Denis Jullien13. 1. Department of Dermatology at Hôpital Edouard Herriot, Université Claude Bernard Lyon 1, Lyon, France. Electronic address: axel.villani@chu-lyon.fr. 2. Department of Dermatology, Hôpital Haut-Lévêque, Université de Bordeaux, Bordeaux, France. 3. Department of Dermatology, Hôpital Morvan, Université de Bretagne, Brest, France. 4. Méthodomics, Mortagne-sur-Sèvre, France. 5. Department of Dermatology, Centre Hospitalier Universitaire de Toulouse, Université Paul Sabatier, Toulouse, France. 6. Department of Dermatology, Hôpital de la Timone, Université de la Méditerranée Aix Marseille II, Marseille, France. 7. Department of Dermatology, Hôpital Charles-Nicolle, Université de Rouen, Rouen, France. 8. private practice, Caen, France. 9. Department of Dermatology, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Université René Descartes, Paris, France. 10. Department of Dermatology, Hôpital Saint-Jacques, Université de Franche-Comté, Besançon, France. 11. Department of Rheumatology, Centre Hospitalier Universitaire de Toulouse, Université Paul Sabatier, Toulouse, France. 12. Department of Dermatology, Hôpital Archet, Centre Hospitalier Universitaire de Nice, Nice, France. 13. Department of Dermatology at Hôpital Edouard Herriot, Université Claude Bernard Lyon 1, Lyon, France.
Abstract
BACKGROUND: Skin psoriasis precedes the onset of psoriatic arthritis (PsA) in 84% of patients with psoriasis. Dermatologists have an important role to screen psoriasis patients for PsA. The efficiency of PsA screening remains unknown. OBJECTIVE: We sought to determine the point prevalence of undiagnosed PsA in patients with psoriasis using a systematic search of the literature and meta-analysis. METHODS: PubMed, Cochrane, and Embase database searches yielded 394 studies for review. No study aimed to determine the prevalence of undiagnosed PsA in patients with psoriasis. We assumed that the prevalence of newly diagnosed PsA in patients with psoriasis at the time they seek medical care could be a sound estimate of this value. Seven epidemiological studies and 5 studies on PsA screening questionnaires allowed us to clearly identify patients with newly diagnosed PsA and were selected for review. RESULTS: The prevalence of undiagnosed PsA was 15.5% when all studies were considered and 10.1% when only epidemiological studies were considered. LIMITATIONS: Data were obtained from studies not designed to address the question at hand. Heterogeneity was high (I(2) = 96.86%), and therefore a random effects model was used. CONCLUSION: The high prevalence of undiagnosed PsA in patients with psoriasis adds to the recommendation that dermatologists need to screen all patients with psoriasis for PsA.
BACKGROUND: Skin psoriasis precedes the onset of psoriatic arthritis (PsA) in 84% of patients with psoriasis. Dermatologists have an important role to screen psoriasispatients for PsA. The efficiency of PsA screening remains unknown. OBJECTIVE: We sought to determine the point prevalence of undiagnosed PsA in patients with psoriasis using a systematic search of the literature and meta-analysis. METHODS: PubMed, Cochrane, and Embase database searches yielded 394 studies for review. No study aimed to determine the prevalence of undiagnosed PsA in patients with psoriasis. We assumed that the prevalence of newly diagnosed PsA in patients with psoriasis at the time they seek medical care could be a sound estimate of this value. Seven epidemiological studies and 5 studies on PsA screening questionnaires allowed us to clearly identify patients with newly diagnosed PsA and were selected for review. RESULTS: The prevalence of undiagnosed PsA was 15.5% when all studies were considered and 10.1% when only epidemiological studies were considered. LIMITATIONS: Data were obtained from studies not designed to address the question at hand. Heterogeneity was high (I(2) = 96.86%), and therefore a random effects model was used. CONCLUSION: The high prevalence of undiagnosed PsA in patients with psoriasis adds to the recommendation that dermatologists need to screen all patients with psoriasis for PsA.
Authors: Ennio Lubrano; Andrea Delle Sedie; Marco Romanelli; Maria Sole Chimenti; Luca Bianchi; Stefano Piaserico; Catia De Felice; Dario Graceffa; Maria Ilenia De Andres; Salvatore Curatolo; Rosa Daniela Grembiale; Stefano Dastoli; Chiara Arcuri; Rosa Giuseppa Angileri; Francesca Prignano; Francesca Bandinelli; Elena Baldissera; Santo Raffaele Mercuri; Chiara Franchi; Matteo Longhi; Angela Patrì; Francesco Caso; Giuseppe Passiu; Maria Antonia Montesu; Simone Parisi; Elena Stroppiana; Genoveffa Scotto di Luzio; Giovanni Italiano; Sergio Di Nuzzo; Daniele Santilli; Laura Bigi; Federica Lumetti; Concetto Paolo Agnusdei; Maria Grazia Ferrucci; Giuliana Gualberti; Francesca Marando; Roberta Ramonda; Francesco Cusano Journal: Clin Rheumatol Date: 2020-11-06 Impact factor: 2.980