Catalytic enantioselective synthesis of planar-chiral cyclic amides based on a Pd-catalyzed asymmetric allylic substitution reaction.

The highly enantioselective synthesis of planar-chiral nine-membered cyclic amides was achieved by the Pd-catalyzed asymmetric allylic cyclization of achiral linear precursors in the presence of a catalytic amount of chiral ligand.