| Literature DB >> 26053403 |
Robert A Power1, Stacy Steinberg2, Gyda Bjornsdottir2, Cornelius A Rietveld3, Abdel Abdellaoui4, Michel M Nivard4, Magnus Johannesson5, Tessel E Galesloot6, Jouke J Hottenga4, Gonneke Willemsen4, David Cesarini7, Daniel J Benjamin8, Patrik K E Magnusson9, Fredrik Ullén10, Henning Tiemeier11, Albert Hofman11, Frank J A van Rooij11, G Bragi Walters2, Engilbert Sigurdsson12, Thorgeir E Thorgeirsson2, Andres Ingason2, Agnar Helgason13, Augustine Kong2, Lambertus A Kiemeney6, Philipp Koellinger14, Dorret I Boomsma4, Daniel Gudbjartsson2, Hreinn Stefansson2, Kari Stefansson13.
Abstract
We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10(-6) and 3.8 × 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.Entities:
Mesh：
Year: 2015 PMID： 26053403 DOI： 10.1038/nn.4040
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884