S Roehr1, T Luck1,2, H Bickel3, C Brettschneider4, A Ernst5, A Fuchs6, K Heser7, H-H König4, F Jessen8,9, C Lange5, E Mösch3, M Pentzek6, S Steinmann10, S Weyerer11, J Werle11, B Wiese10, M Scherer5, W Maier7,9, S G Riedel-Heller1. 1. Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany. 2. LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. 3. Department of Psychiatry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. 4. Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 5. Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center, Hamburg-Eppendorf, Germany. 6. Institute of General Practice, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. 7. Department of Psychiatry, University of Bonn, Bonn, Germany. 8. Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany. 9. German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany. 10. Work Group Medical Statistics and IT-Infrastructure, Institute for General Practice, Hannover Medical School, Hannover, Germany. 11. Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Abstract
OBJECTIVE: Dementia is known to increase mortality, but the relative loss of life years and contributing factors are not well established. Thus, we aimed to investigate mortality in incident dementia from disease onset. METHOD: Data were derived from the prospective longitudinal German AgeCoDe study. We used proportional hazards models to assess the impact of sociodemographic and health characteristics on mortality after dementia onset, Kaplan-Meier method for median survival times. RESULTS: Of 3214 subjects at risk, 523 (16.3%) developed incident dementia during a 9-year follow-up period. Median survival time after onset was 3.2 years (95% CI = 2.8-3.7) at a mean age of 85.0 (SD = 4.0) years (≥2.6 life years lost compared with the general German population). Survival was shorter in older age, males other dementias than Alzheimer's, and in the absence of subjective memory complaints (SMC). CONCLUSION: Our findings emphasize that dementia substantially shortens life expectancy. Future studies should further investigate the potential impact of SMC on mortality in dementia.
OBJECTIVE:Dementia is known to increase mortality, but the relative loss of life years and contributing factors are not well established. Thus, we aimed to investigate mortality in incident dementia from disease onset. METHOD: Data were derived from the prospective longitudinal German AgeCoDe study. We used proportional hazards models to assess the impact of sociodemographic and health characteristics on mortality after dementia onset, Kaplan-Meier method for median survival times. RESULTS: Of 3214 subjects at risk, 523 (16.3%) developed incident dementia during a 9-year follow-up period. Median survival time after onset was 3.2 years (95% CI = 2.8-3.7) at a mean age of 85.0 (SD = 4.0) years (≥2.6 life years lost compared with the general German population). Survival was shorter in older age, males other dementias than Alzheimer's, and in the absence of subjective memory complaints (SMC). CONCLUSION: Our findings emphasize that dementia substantially shortens life expectancy. Future studies should further investigate the potential impact of SMC on mortality in dementia.
Authors: Zoe Arvanitakis; Sue E Leurgans; Debra A Fleischman; Julie A Schneider; Kumar B Rajan; Jeremy J Pruzin; Raj C Shah; Denis A Evans; Lisa L Barnes; David A Bennett Journal: Ann Neurol Date: 2018-03-30 Impact factor: 10.422
Authors: Gregory Huyer; Catherine R L Brown; Sarah Spruin; Amy T Hsu; Stacey Fisher; Douglas G Manuel; Susan E Bronskill; Danial Qureshi; Peter Tanuseputro Journal: CMAJ Date: 2020-04-20 Impact factor: 8.262
Authors: Jessica Grothe; Susanne Röhr; Melanie Luppa; Alexander Pabst; Luca Kleineidam; Kathrin Heser; Angela Fuchs; Michael Pentzek; Anke Oey; Birgitt Wiese; Dagmar Lühmann; Hendrik van den Bussche; Siegfried Weyerer; Jochen Werle; Dagmar Weeg; Horst Bickel; Martin Scherer; Hans-Helmut König; André Hajek; Michael Wagner; Steffi G Riedel-Heller Journal: Front Psychiatry Date: 2022-06-10 Impact factor: 5.435