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Literature DB >> 26052598

Use of ciprofloxacin during breastfeeding.

Abstract

QUESTION: My patient has a urinary tract infection and is currently breastfeeding her 9-week-old son. I would like to prescribe her ciprofloxacin. Should I be concerned about osteoarticular toxicity in the infant? ANSWER: Although there are concerns about the possible risk of osteoarticular toxicity with ciprofloxacin, the amounts excreted into breast milk are low and studies report no substantial increase in osteoarticular toxicity even with the systemic use of ciprofloxacin in neonates and children. Therefore, interrupting breastfeeding during ciprofloxacin treatment appears unnecessary.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2015 PMID： 26052598 PMCID： PMC4396759

Source DB: PubMed Journal: Can Fam Physician ISSN： 0008-350X Impact factor: 3.275

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References

21 in total

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Journal: Clin Pharm Date: 1992-04

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Authors: P Lumbiganon; K Pengsaa; T Sookpranee
Journal: Pediatr Infect Dis J Date: 1991-08 Impact factor: 2.129

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Authors: Florentia Kaguelidou; Mark A Turner; Imti Choonara; Evelyne Jacqz-Aigrain
Journal: Pediatr Infect Dis J Date: 2011-02 Impact factor: 2.129

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Journal: Acta Obstet Gynecol Scand Date: 2012-11-01 Impact factor: 3.636

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Authors: Peter C Drobac; Hernan del Castillo; Annika Sweetland; Genaro Anca; J Keith Joseph; Jennifer Furin; Sonya Shin
Journal: Clin Infect Dis Date: 2005-04-18 Impact factor: 9.079

Use of ciprofloxacin during breastfeeding.

1. Simultaneous concentrations of ciprofloxacin in breast milk and in serum in mother and breast-fed infant.

2. Ciprofloxacin in neonates and its possible adverse effect on the teeth.

Review 3. Ciprofloxacin use in neonates: a systematic review of the literature.

4. Postpartum infections: occurrence, healthcare contacts and association with breastfeeding.

5. Treatment of multidrug-resistant tuberculosis during pregnancy: long-term follow-up of 6 children with intrauterine exposure to second-line agents.

6. Toxicological studies on pipemidic acid. V. Effect on diarthrodial joints of experimental animals.

7. Perforated pseudomembranous colitis in the breast-fed infant.

8. Ciprofloxacin penetration into human breast milk: a case report.

Review 9. Ciprofloxacin safety in paediatrics: a systematic review.

Review 10. Mechanism of quinolone action and resistance.