Mogahid Y Nassar1, Hassan A Al-Shamahy2, Haitham A A Masood3. 1. Department of Clinical Pathology & Immunology, Faculty of Medical Sciences, University of Sciences & Technology, Sana'a, Yemen; 2. Department of Medical Microbiology & Clinical Immunology, Faculty of Medicine & Health Sciences, Sana'a University, Sana'a, Yemen; 3. Department of Clinical Immunology, Al-Thorah University Hospital, Sana'a, Yemen; ; Yemen Ministry of Public Health, Sana'a, Yemen.
Abstract
OBJECTIVES: Many studies have attempted to locate a connection between various genetic factors and the pathogenesis of certain diseases. A number of these have found human leukocyte antigens (HLAs) to be the most significant genetic factors affecting the susceptibility of an individual to a certain disease. The present case-control study aimed to determine the connection between class I and class II HLAs and cases of hypertensive end-stage renal failure (HESRF), as contrasted with healthy controls, in Yemen. METHODS: The study was carried out between March 2013 and March 2014 and included 50 HESRF patients attending the Urology & Nephrology Center at Al-Thawra University Hospital in Sana'a, Yemen, and 50 healthy controls visiting the same centre for kidney donation. Among both patients and controls, HLA class I (A, B and C) and class II (DRB1) genotypes were determined by polymerase chain reactions. RESULTS: There was an association (odds ratio: 4.0) with HLA-A9(24) and HESRF, although this was not statistically significant. A significant protective function was found for the HLA-CW3 and DRB1-8 genes against the development of HESRF. Although HLA-B14 was present in some patients (0.06) and not in the controls, this difference was not statistically significant enough to conclude that HLA-B14 plays a role in the genetic predisposition for end-stage renal disease development. There was a high frequency of HLA-A2, B5, CW6, DRB1-3, DRB1-4 and DRB1-13 in both patients and controls. CONCLUSION: Although no HLAs were found to play a highly significant role in genetic predisposition to HESRF, certain HLA genes could be considered as protective genes against HESRF development.
OBJECTIVES: Many studies have attempted to locate a connection between various genetic factors and the pathogenesis of certain diseases. A number of these have found human leukocyte antigens (HLAs) to be the most significant genetic factors affecting the susceptibility of an individual to a certain disease. The present case-control study aimed to determine the connection between class I and class II HLAs and cases of hypertensive end-stage renal failure (HESRF), as contrasted with healthy controls, in Yemen. METHODS: The study was carried out between March 2013 and March 2014 and included 50 HESRF patients attending the Urology & Nephrology Center at Al-Thawra University Hospital in Sana'a, Yemen, and 50 healthy controls visiting the same centre for kidney donation. Among both patients and controls, HLA class I (A, B and C) and class II (DRB1) genotypes were determined by polymerase chain reactions. RESULTS: There was an association (odds ratio: 4.0) with HLA-A9(24) and HESRF, although this was not statistically significant. A significant protective function was found for the HLA-CW3 and DRB1-8 genes against the development of HESRF. Although HLA-B14 was present in some patients (0.06) and not in the controls, this difference was not statistically significant enough to conclude that HLA-B14 plays a role in the genetic predisposition for end-stage renal disease development. There was a high frequency of HLA-A2, B5, CW6, DRB1-3, DRB1-4 and DRB1-13 in both patients and controls. CONCLUSION: Although no HLAs were found to play a highly significant role in genetic predisposition to HESRF, certain HLA genes could be considered as protective genes against HESRF development.
Authors: D T Lackland; T J Orchard; J E Keil; D E Saunders; F C Wheeler; L L Adams-Campbell; R H McDonald; R G Knapp Journal: Int J Epidemiol Date: 1992-04 Impact factor: 7.196
Authors: V Valluri; V Valluei; M Mustafa; A Santhosh; D Middleton; M Alvares; M Alvales; E El Haj; O Gumama; L Abdel-Wareth; L Abdel-Waieth Journal: Tissue Antigens Date: 2005-08
Authors: Ibrahiem H El-Nono; Tawfiq H Al-Ba'adani; Abdulilah M Ghilan; Nagieb W Abu Asba; Gamil M Al-Alimy; Mokhtar M Al-Massani; Morshed A Noman; Soliman Al-Shargabe; Mohamed M Al-Mansour; Mogahed Y Nassar Journal: Saudi J Kidney Dis Transpl Date: 2007-06
Authors: M A Droguett; R Beltran; R Ardiles; N Raddatz; C Labraña; A Arenas; J Flores; P Alruiz; S Mezzano; L Ardiles Journal: Transplant Proc Date: 2008-06-20 Impact factor: 1.066