BACKGROUND: The association of nephrotic syndrome (NS) and Hodgkin's lymphoma (HL), although rare, is well recognised. In the majority of cases of HL, minimal change NS is detected. DESCRIPTION OF CASES: This report presents the occurrence of NS in two children with HL. In the first case, NS preceded the diagnosis of lymphoma by 3 months, while in the other child, the two disorders occurred simultaneously. In both cases, clinical manifestations and laboratory parameters (proteinuria) of NS resolved after effective treatment for active HL. CONCLUSION: Prolonged proteinuria may be a paraneoplastic syndrome and HL should be considered in the diagnosis as it is crucial for the management of both entities.
BACKGROUND: The association of nephrotic syndrome (NS) and Hodgkin's lymphoma (HL), although rare, is well recognised. In the majority of cases of HL, minimal change NS is detected. DESCRIPTION OF CASES: This report presents the occurrence of NS in two children with HL. In the first case, NS preceded the diagnosis of lymphoma by 3 months, while in the other child, the two disorders occurred simultaneously. In both cases, clinical manifestations and laboratory parameters (proteinuria) of NS resolved after effective treatment for active HL. CONCLUSION: Prolonged proteinuria may be a paraneoplastic syndrome and HL should be considered in the diagnosis as it is crucial for the management of both entities.
Authors: V Audard; F Larousserie; P Grimbert; M Abtahi; J-J Sotto; A Delmer; F Boue; D Nochy; N Brousse; R Delarue; P Remy; P Ronco; D Sahali; P Lang; O Hermine Journal: Kidney Int Date: 2006-05-03 Impact factor: 10.612