Literature DB >> 26051448

Assembly of bioactive multilayered nanocoatings on pancreatic islet cells: incorporation of α1-antitrypsin into the coatings.

Zheng-Liang Zhi1, Jashandeep Singh, Amazon L F Austin, David C D Hope, Aileen J King, Shanta J Persaud, Peter M Jones.   

Abstract

A spontaneous multilayer deposition approach for presenting therapeutic proteins onto pancreatic islet surfaces, using a heparin polyaldehyde and glycol chitosan alternating layering scheme, has been developed to enable the nanoscale engineering of a microenvironment for transplanted cells. The nanocoating incorporating α1-antitrypsin, an anti-inflammatory protein, exhibited effective anti-coagulant activities in vitro.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26051448     DOI： 10.1039/c5cc02570b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

Review 1.  Improving cell-based therapies by nanomodification.

Authors:  Wei Chen; Liwu Fu; Xiaoyuan Chen
Journal:  J Control Release       Date:  2015-09-28       Impact factor: 9.776

2.  Transplantation of PEGylated islets enhances therapeutic efficacy in a diabetic nonhuman primate model.

Authors:  Cherie L Stabler; Jaime A Giraldo; Dora M Berman; Kerim M Gattás-Asfura; Melissa A Willman; Alexander Rabassa; James Geary; Waldo Diaz; Norman M Kenyon; Norma S Kenyon
Journal:  Am J Transplant       Date:  2019-11-13       Impact factor: 8.086

3.  Engineering immunomodulatory biomaterials for type 1 diabetes.

Authors:  C L Stabler; Y Li; J M Stewart; B G Keselowsky
Journal:  Nat Rev Mater       Date:  2019-05-17       Impact factor: 66.308

4.  Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating.

Authors:  Jingyi Yang; Shaofeng Lou; Deling Kong; Chen Li
Journal:  J Vis Exp       Date:  2018-06-23       Impact factor: 1.355

5.  Imatinib prevents beta cell death in vitro but does not improve islet transplantation outcome.

Authors:  Aileen J F King; Lisa A Griffiths; Shanta J Persaud; Peter M Jones; Simon L Howell; Nils Welsh
Journal:  Ups J Med Sci       Date:  2016-03-08       Impact factor: 2.384

6.  An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles.

Authors:  Brian C Evans; R Brock Fletcher; Kameron V Kilchrist; Eric A Dailing; Alvin J Mukalel; Juan M Colazo; Matthew Oliver; Joyce Cheung-Flynn; Colleen M Brophy; John W Tierney; Jeffrey S Isenberg; Kurt D Hankenson; Kedar Ghimire; Cynthia Lander; Charles A Gersbach; Craig L Duvall
Journal:  Nat Commun       Date:  2019-11-01       Impact factor: 14.919
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.