Literature DB >> 26051118

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC).

João P M Nunes1, Maurício Morais, Vessela Vassileva, Eifion Robinson, Vineeth S Rajkumar, Mark E B Smith, R Barbara Pedley, Stephen Caddick, James R Baker, Vijay Chudasama.   

Abstract

Herein we report the use of next generation maleimides (NGMs) for the construction of a potent antibody-drug conjugate (ADC) via functional disulfide bridging. The linker has excellent stability in blood serum and the ADC, armed with monomethyl auristatin E (MMAE), shows excellent potency and cancer cell selectivity in vitro.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26051118     DOI： 10.1039/c5cc03557k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  31 in total

1.  Recent advances in the construction of antibody-drug conjugates.

Authors:  Vijay Chudasama; Antoine Maruani; Stephen Caddick
Journal:  Nat Chem       Date:  2016-01-04       Impact factor: 24.427

2.  N-substituted methyl maleamates as larvicidal compounds against Aedes aegypti (Diptera: Culicidae).

Authors:  Laura Harburguer; Paula V Gonzalez; Paola Gonzalez Audino; Eduardo Zerba; Héctor Masuh
Journal:  Parasitol Res       Date:  2017-12-30       Impact factor: 2.289

3.  Pyrocinchonimides Conjugate to Amine Groups on Proteins via Imide Transfer.

Authors:  Mark B Richardson; Kristin N Gabriel; Joseph A Garcia; Shareen N Ashby; Rebekah P Dyer; Joshua K Kim; Calvin J Lau; John Hong; Ryan J Le Tourneau; Sanjana Sen; David L Narel; Benjamin B Katz; Joseph W Ziller; Sudipta Majumdar; Philip G Collins; Gregory A Weiss
Journal:  Bioconjug Chem       Date:  2020-04-30       Impact factor: 4.774

4.  Expanding the Scope of Antibody Rebridging with New Pyridazinedione-TCO Constructs.

Authors:  Angela N Marquard; Jonathan C T Carlson; Ralph Weissleder
Journal:  Bioconjug Chem       Date:  2020-04-28       Impact factor: 4.774

5.  DiPODS: A Reagent for Site-Specific Bioconjugation via the Irreversible Rebridging of Disulfide Linkages.

Authors:  Elaheh Khozeimeh Sarbisheh; Guillaume Dewaele-Le Roi; Whitney E Shannon; Sally Tan; Yujia Xu; Brian M Zeglis; Eric W Price
Journal:  Bioconjug Chem       Date:  2020-11-19       Impact factor: 4.774

6.  Reduction-rebridging strategy for the preparation of ADPN-based antibody-drug conjugates.

Authors:  Oleksandr Koniev; Igor Dovgan; Brigitte Renoux; Anthony Ehkirch; Jitka Eberova; Sarah Cianférani; Sergii Kolodych; Sébastien Papot; Alain Wagner
Journal:  Medchemcomm       Date:  2018-04-20       Impact factor: 3.597

7.  Precision Modification of Native Antibodies.

Authors:  Kuan-Lin Wu; Chenfei Yu; Catherine Lee; Chao Zuo; Zachary T Ball; Han Xiao
Journal:  Bioconjug Chem       Date:  2021-08-24       Impact factor: 4.774

8.  A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine.

Authors:  Mark E B Smith; Mikael B Caspersen; Eifion Robinson; Maurício Morais; Antoine Maruani; João P M Nunes; Karl Nicholls; Malcolm J Saxton; Stephen Caddick; James R Baker; Vijay Chudasama
Journal:  Org Biomol Chem       Date:  2015-06-25       Impact factor: 3.876

Review 9.  Linkers Having a Crucial Role in Antibody-Drug Conjugates.

Authors:  Jun Lu; Feng Jiang; Aiping Lu; Ge Zhang
Journal:  Int J Mol Sci       Date:  2016-04-14       Impact factor: 5.923

10.  New Bifunctional Chelators Incorporating Dibromomaleimide Groups for Radiolabeling of Antibodies with Positron Emission Tomography Imaging Radioisotopes.

Authors:  Matthew Farleigh; Truc Thuy Pham; Zilin Yu; Jana Kim; Kavitha Sunassee; George Firth; Nafsika Forte; Vijay Chudasama; James R Baker; Nicholas J Long; Charlotte Rivas; Michelle T Ma
Journal:  Bioconjug Chem       Date:  2021-03-16       Impact factor: 4.774
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.