Chuan Li1, Jing-Yi Zhang2, Xiao-Yun Zhang1, Tian-Fu Wen3, Lu-Nan Yan1. 1. Division of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, China. 2. Division of Ultrasonography, West China Hospital of Sichuan University, Chengdu 610041, China. 3. Division of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address: ccwentianfu@sohu.com.
Abstract
OBJECTIVE: To assess the correlation of preoperative FibroScan value and postoperative ascites in patients undergoing liver resection for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC). METHODS: A prospective study group of consecutive HBV-related HCC patients considered eligible for liver resection was conducted from 2012 to 2014 (N = 77). Liver stiffness measured by FibroScan was administrated to all patients. Patient's pre- and intra-operative variables were prospectively collected. RESULTS: FibroScan was successfully performed in 75 patients. Postoperative ascites was observed in 13 patients. Univariate analyses suggested tumor size, high preoperative hepatitis B viral load, intraoperative blood loss, major hepatectomy and FibroScan value were potential risk factors for postoperative ascites. However, in multivariate analysis, only FibroScan value (OR = 1.506, 95%CI = 1.21-1.87) showed prognostic power. The best cut-off value of FibroScan value to predict postoperative ascites was 15.6 kpa with a sensitivity of 76.9% and a specificity of 98.4%. The corresponding area under the receiver operating curve was 0.902. CONCLUSIONS: FibroScan value was a reliable surrogate marker for predicting postoperative ascites should be routinely performed in patients with HBV-related HCC undergoing liver resection.
OBJECTIVE: To assess the correlation of preoperative FibroScan value and postoperative ascites in patients undergoing liver resection for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC). METHODS: A prospective study group of consecutive HBV-related HCC patients considered eligible for liver resection was conducted from 2012 to 2014 (N = 77). Liver stiffness measured by FibroScan was administrated to all patients. Patient's pre- and intra-operative variables were prospectively collected. RESULTS: FibroScan was successfully performed in 75 patients. Postoperative ascites was observed in 13 patients. Univariate analyses suggested tumor size, high preoperative hepatitis B viral load, intraoperative blood loss, major hepatectomy and FibroScan value were potential risk factors for postoperative ascites. However, in multivariate analysis, only FibroScan value (OR = 1.506, 95%CI = 1.21-1.87) showed prognostic power. The best cut-off value of FibroScan value to predict postoperative ascites was 15.6 kpa with a sensitivity of 76.9% and a specificity of 98.4%. The corresponding area under the receiver operating curve was 0.902. CONCLUSIONS: FibroScan value was a reliable surrogate marker for predicting postoperative ascites should be routinely performed in patients with HBV-related HCC undergoing liver resection.
Authors: Gil Ho Lee; Hyo Jung Cho; Garam Lee; Han Gyeol Kim; Hee Jung Wang; Bong-Wan Kim; Mi Young Lee; So Young Yoon; Choong-Kyun Noh; Chul Won Seo; Jung Woo Eun; Jae Youn Cheong; Sung Won Cho; Soon Sun Kim Journal: Ann Transl Med Date: 2021-02