Goldi A Kozloski1, Izidore S Lossos. 1. aDivision of Hematology-Oncology, Department of Medicine bDepartment of Molecular and Cellular Pharmacology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA.
Abstract
PURPOSE OF REVIEW: This review provides current knowledge on the role of microRNAs (miRNAs) in lymphoma with an emphasis on mature B-cell lymphoma. RECENT FINDINGS: Although miRNAs were previously used to stratify lymphoma classification, prognosis, or treatment response, recent publications portray this class of small noncoding RNAs as critical players in the lymphomagenesis process. Although functional studies provide ample evidence for their role as lymphoma drivers or suppressors, genetic studies providing the underlying mechanisms for these phenotypes are still lacking. As more whole-genome sequencing of lymphoma cases become available, this gap may be soon filled. SUMMARY: Current findings highlight the potential role of miRNAs molecules as important factors in lymphomagenesis.
PURPOSE OF REVIEW: This review provides current knowledge on the role of microRNAs (miRNAs) in lymphoma with an emphasis on mature B-cell lymphoma. RECENT FINDINGS: Although miRNAs were previously used to stratify lymphoma classification, prognosis, or treatment response, recent publications portray this class of small noncoding RNAs as critical players in the lymphomagenesis process. Although functional studies provide ample evidence for their role as lymphoma drivers or suppressors, genetic studies providing the underlying mechanisms for these phenotypes are still lacking. As more whole-genome sequencing of lymphoma cases become available, this gap may be soon filled. SUMMARY: Current findings highlight the potential role of miRNAs molecules as important factors in lymphomagenesis.
Authors: Giorgio Malpeli; Stefano Barbi; Corinna Greco; Simonetta Zupo; Anna Bertolaso; Maria Teresa Scupoli; Mauro Krampera; Paul Takam Kamga; Carlo Maria Croce; Aldo Scarpa; Alberto Zamò Journal: Oncotarget Date: 2018-04-13